Infra-slow fluctuations in cortical potentials and respiration drive fast cortical EEG rhythms in sleeping and waking states
Väyrynen, Tommi; Helakari, Heta; Korhonen, Vesa; Tuunanen, Johanna; Huotari, Niko; Piispala, Johanna; Kallio, Mika; Raitamaa, Lauri; Kananen, Janne; Järvelä, Matti; Matias Palva, J.; Kiviniemi, Vesa (2023-11-03)
Väyrynen, Tommi
Helakari, Heta
Korhonen, Vesa
Tuunanen, Johanna
Huotari, Niko
Piispala, Johanna
Kallio, Mika
Raitamaa, Lauri
Kananen, Janne
Järvelä, Matti
Matias Palva, J.
Kiviniemi, Vesa
Elsevier
03.11.2023
Väyrynen, T., Helakari, H., Korhonen, V., Tuunanen, J., Huotari, N., Piispala, J., Kallio, M., Raitamaa, L., Kananen, J., Järvelä, M., Matias Palva, J., & Kiviniemi, V. (2023). Infra-slow fluctuations in cortical potentials and respiration drive fast cortical EEG rhythms in sleeping and waking states. In Clinical Neurophysiology (Vol. 156, pp. 207–219). Elsevier BV. https://doi.org/10.1016/j.clinph.2023.10.013.
https://creativecommons.org/licenses/by/4.0/
© 2023 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
https://creativecommons.org/licenses/by/4.0/
© 2023 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
https://creativecommons.org/licenses/by/4.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202312083592
https://urn.fi/URN:NBN:fi:oulu-202312083592
Tiivistelmä
Abstract
Objective:
Infra-slow fluctuations (ISF, 0.008–0.1 Hz) characterize hemodynamic and electric potential signals of human brain. ISFs correlate with the amplitude dynamics of fast (>1 Hz) neuronal oscillations, and may arise from permeability fluctuations of the blood–brain barrier (BBB). It is unclear if physiological rhythms like respiration drive or track fast cortical oscillations, and the role of sleep in this coupling is unknown.
Methods:
We used high-density full-band electroencephalography (EEG) in healthy human volunteers (N = 21) to measure concurrently the ISFs, respiratory pulsations, and fast neuronal oscillations during periods of wakefulness and sleep, and to assess the strength and direction of their phase-amplitude coupling.
Results:
The phases of ISFs and respiration were both coupled with the amplitude of fast neuronal oscillations, with stronger ISF coupling being evident during sleep. Phases of ISF and respiration drove the amplitude dynamics of fast oscillations in sleeping and waking states, with different contributions.
Conclusions:
ISFs in slow cortical potentials and respiration together significantly determine the dynamics of fast cortical oscillations.
Significance:
We propose that these slow physiological phases play a significant role in coordinating cortical excitability, which is a fundamental aspect of brain function.
Objective:
Infra-slow fluctuations (ISF, 0.008–0.1 Hz) characterize hemodynamic and electric potential signals of human brain. ISFs correlate with the amplitude dynamics of fast (>1 Hz) neuronal oscillations, and may arise from permeability fluctuations of the blood–brain barrier (BBB). It is unclear if physiological rhythms like respiration drive or track fast cortical oscillations, and the role of sleep in this coupling is unknown.
Methods:
We used high-density full-band electroencephalography (EEG) in healthy human volunteers (N = 21) to measure concurrently the ISFs, respiratory pulsations, and fast neuronal oscillations during periods of wakefulness and sleep, and to assess the strength and direction of their phase-amplitude coupling.
Results:
The phases of ISFs and respiration were both coupled with the amplitude of fast neuronal oscillations, with stronger ISF coupling being evident during sleep. Phases of ISF and respiration drove the amplitude dynamics of fast oscillations in sleeping and waking states, with different contributions.
Conclusions:
ISFs in slow cortical potentials and respiration together significantly determine the dynamics of fast cortical oscillations.
Significance:
We propose that these slow physiological phases play a significant role in coordinating cortical excitability, which is a fundamental aspect of brain function.
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