Light source-detector pair positioning to optimize tagging efficiency of focused ultrasound-modulated photons in a backward detection mode
Omidali, Mohammadreza; Mardanshahi, Ali; Zhao, Zuomin; Sonker, Deepak; Bykov, Alexander; Myllylä, Teemu (2023-03-09)
SPIE
09.03.2023
Mohammadreza Omidali, Ali Mardanshahi, Zuomin Zhao, Deepak Sonker, Alexander Bykov, and Teemu Myllylä "Light source-detector pair positioning to optimize tagging efficiency of focused ultrasound-modulated photons in a backward detection mode", Proc. SPIE 12379, Photons Plus Ultrasound: Imaging and Sensing 2023, 123791N (9 March 2023); https://doi.org/10.1117/12.2650594
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Copyright 2023 Society of Photo‑Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, and modification of the contents of the publication are prohibited.
https://rightsstatements.org/vocab/InC/1.0/
Copyright 2023 Society of Photo‑Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, and modification of the contents of the publication are prohibited.
https://rightsstatements.org/vocab/InC/1.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202505133323
https://urn.fi/URN:NBN:fi:oulu-202505133323
Tiivistelmä
Abstract
Focusing Ultrasound (FUS) can be used to modulate diffusing light in tissue. In this method, diffused photons are modulated in the ultrasound focus area. Detecting these FUS modulated (or tagged) photons can provide spatially accurate information from the focus area. However, probably the biggest challenge in this method is to enable sufficient tagging photons since most of the illuminated and detected photons do not propagate thru the FUS target area resulting in a low number of tagged photons when compared to the background unmodulated light. Therefore, current applications utilizing such hybrid technique are still limited. Our study aims to optimize illumination and detection of photons that propagate through a FUS target area by adjusting the relative position and angle of a light source-detector pair. For the simulations, the K-wave toolbox was utilized to calculate the nonlinear acoustic pressure field in the discretized numerical model from the FUS source. Furthermore, light propagation in the model is simulated using an open-source Monte Carlo algorithm. The model design is a backward detection mode which is suitable for direct application to the human body.
Focusing Ultrasound (FUS) can be used to modulate diffusing light in tissue. In this method, diffused photons are modulated in the ultrasound focus area. Detecting these FUS modulated (or tagged) photons can provide spatially accurate information from the focus area. However, probably the biggest challenge in this method is to enable sufficient tagging photons since most of the illuminated and detected photons do not propagate thru the FUS target area resulting in a low number of tagged photons when compared to the background unmodulated light. Therefore, current applications utilizing such hybrid technique are still limited. Our study aims to optimize illumination and detection of photons that propagate through a FUS target area by adjusting the relative position and angle of a light source-detector pair. For the simulations, the K-wave toolbox was utilized to calculate the nonlinear acoustic pressure field in the discretized numerical model from the FUS source. Furthermore, light propagation in the model is simulated using an open-source Monte Carlo algorithm. The model design is a backward detection mode which is suitable for direct application to the human body.
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