Long-term impact of physical activity on the prevention of cognitive function decline: study protocol for an extended randomized controlled trial (PA Protect study)
Adamczak, Ada Maria; Jamka, Malgorzata; Kotecka, Klaudia; Makarewicz-Bukowska, Aleksandra; Brylak, Jan; Dzudzewicz, Anna; Madry, Edyta; Nowak, Jan Krzysztof; Herzig, Karl-Heinz; Walkowiak, Jaroslaw (2025-03-31)
Poznan University of Medical Sciences
31.03.2025
Adamczak, A. M., Jamka, M., Kotecka, K., Makarewicz-Bukowska, A., Brylak, J., Dzudzewicz, A., Mądry, E., Nowak, J. K., Herzig, K.-H., & Walkowiak, J. (2025). Long-term impact of physical activity on the prevention of cognitive function decline: Study protocol for an extended randomized controlled trial (PA Protect study). Journal of Medical Science, 94(1), e1240. https://doi.org/10.20883/medical.e1240
https://creativecommons.org/licenses/by-nc/4.0/
© 2025 by the author(s). This is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC) licencse. Published by Poznan University of Medical Science.
https://creativecommons.org/licenses/by-nc/4.0/
© 2025 by the author(s). This is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC) licencse. Published by Poznan University of Medical Science.
https://creativecommons.org/licenses/by-nc/4.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202505063115
https://urn.fi/URN:NBN:fi:oulu-202505063115
Tiivistelmä
Abstract
The PA Protect study investigated the impact of increased daily physical activity on preventing cognitive decline, and maintaining healthy biomarker levels in individuals with mild cognitive impairment. Participants aged 50-70 years, selected based on their performance in the Montreal Cognitive Assessment test were enrolled in a double-blind randomized controlled trial and randomly assigned to either an active or passive group. The active group was instructed to achieve over 10,000 daily steps, while the passive group maintained usual activity levels. Preliminary findings revealed a positive influence of increased physical activity on cognitive function, with significant differences observed between the two groups in selected cognitive tests. Building on these results, this study extends the PA Protect trial for an additional three years. All participants will undergo cognitive assessments and biomarker analyses at the beginning and after the extended intervention period, providing further insights into long-term intervention effects.
The PA Protect study investigated the impact of increased daily physical activity on preventing cognitive decline, and maintaining healthy biomarker levels in individuals with mild cognitive impairment. Participants aged 50-70 years, selected based on their performance in the Montreal Cognitive Assessment test were enrolled in a double-blind randomized controlled trial and randomly assigned to either an active or passive group. The active group was instructed to achieve over 10,000 daily steps, while the passive group maintained usual activity levels. Preliminary findings revealed a positive influence of increased physical activity on cognitive function, with significant differences observed between the two groups in selected cognitive tests. Building on these results, this study extends the PA Protect trial for an additional three years. All participants will undergo cognitive assessments and biomarker analyses at the beginning and after the extended intervention period, providing further insights into long-term intervention effects.
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