Leisure-time physical activity predicts levels of advanced glycation end-products in older women: A 15-year follow up from the Helsinki Birth Cohort Study
Lundström, Mathias; Wasenius, Niko; Eriksson, Mia; Mikkola, Tuija M; Kajantie, Eero; Eriksson, Johan G (2025-05-01)
Wiley-Blackwell
01.05.2025
Lundström M, Wasenius N, Eriksson M, Mikkola TM, Kajantie E, Eriksson JG. Leisure-time physical activity predicts levels of advanced glycation end-products in older women: A 15-year follow up from the Helsinki Birth Cohort Study. Geriatr. Gerontol. Int. 2025; 1–8. https://doi.org/10.1111/ggi.70049
https://creativecommons.org/licenses/by/4.0/
© 2025 The Author(s). Geriatrics & Gerontology International published by John Wiley & Sons Australia, Ltd on behalf of Japan Geriatrics Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
https://creativecommons.org/licenses/by/4.0/
© 2025 The Author(s). Geriatrics & Gerontology International published by John Wiley & Sons Australia, Ltd on behalf of Japan Geriatrics Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
https://creativecommons.org/licenses/by/4.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202505053067
https://urn.fi/URN:NBN:fi:oulu-202505053067
Tiivistelmä
Abstract
Aim:
Physical activity might be able to delay the aging process by reducing levels of advanced glycation end-products (AGEs). However, the influence of physical activity on levels of AGEs remains unclear. We investigated the associations between leisure time physical activity (LTPA) in late midlife and change in LTPA during a 15-year follow up on the levels of AGEs in old age.
Methods:
We analyzed 767 participants from the Helsinki Birth Cohort Study. LTPA was measured with a validated questionnaire in late midlife and in old age. The levels of AGEs were measured by skin autofluorescence in old age. General linear models and restricted cubic regression spline models were used to study the associations between LTPA and AGEs. Analyses were adjusted for age, alcohol consumption, dietary index, smoking, follow-up time, body mass index and socioeconomic status.
Results:
Mean levels of AGEs in women (2.33 AU, SD 0.46) were lower than in men (2.49 AU, SD 0.50, P < 0.001). Women in the lowest LTPA quartile had 0.19 AU (95% CI 0.07–0.32, P = 0.002), 0.21 AU (95% CI 0.09–0.33, P = 0.001) and 0.18 AU (95% CI 0.05–0.31, P = 0.006) higher levels of AGEs compared with women in the second, third and fourth quartile. In the restricted cubic regression spline model, levels of AGEs (P = 0.006) were decreasing with increasing LTPA from 0 to 32 METh/week, after which the association plateaued. No associations were found in men.
Conclusions:
Greater volume of LTPA in late midlife is associated with lower levels of AGEs in skin tissue in old age in women.
Aim:
Physical activity might be able to delay the aging process by reducing levels of advanced glycation end-products (AGEs). However, the influence of physical activity on levels of AGEs remains unclear. We investigated the associations between leisure time physical activity (LTPA) in late midlife and change in LTPA during a 15-year follow up on the levels of AGEs in old age.
Methods:
We analyzed 767 participants from the Helsinki Birth Cohort Study. LTPA was measured with a validated questionnaire in late midlife and in old age. The levels of AGEs were measured by skin autofluorescence in old age. General linear models and restricted cubic regression spline models were used to study the associations between LTPA and AGEs. Analyses were adjusted for age, alcohol consumption, dietary index, smoking, follow-up time, body mass index and socioeconomic status.
Results:
Mean levels of AGEs in women (2.33 AU, SD 0.46) were lower than in men (2.49 AU, SD 0.50, P < 0.001). Women in the lowest LTPA quartile had 0.19 AU (95% CI 0.07–0.32, P = 0.002), 0.21 AU (95% CI 0.09–0.33, P = 0.001) and 0.18 AU (95% CI 0.05–0.31, P = 0.006) higher levels of AGEs compared with women in the second, third and fourth quartile. In the restricted cubic regression spline model, levels of AGEs (P = 0.006) were decreasing with increasing LTPA from 0 to 32 METh/week, after which the association plateaued. No associations were found in men.
Conclusions:
Greater volume of LTPA in late midlife is associated with lower levels of AGEs in skin tissue in old age in women.
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