To shunt or not to shunt when closing myelomeningocele? A systematic review and meta-analysis of simultaneous versus delayed ventriculoperitoneal shunt placement in neonates undergoing myelomeningocele closure
Saarinen, Okko; Piironen, Susanna; Pokka, Tytti; Sinikumpu, Juha-Jaakko; Serlo, Willy; Salokorpi, Niina; Knuutinen, Oula (2024-08-09)
Avaa tiedosto
Sisältö avataan julkiseksi: 09.08.2025
American Association of Neurological Surgeons
09.08.2024
Saarinen, O., Piironen, S., Pokka, T., Sinikumpu, J.-J., Serlo, W., Salokorpi, N., & Knuutinen, O. (2024). To shunt or not to shunt when closing myelomeningocele? A systematic review and meta-analysis of simultaneous versus delayed ventriculoperitoneal shunt placement in neonates undergoing myelomeningocele closure. Journal of Neurosurgery: Pediatrics, 34(5), 452–461. https://doi.org/10.3171/2024.5.PEDS23600
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© Copyright 2025 American Association of Neurological Surgeons. All rights reserved, including those for text and data mining, AI training, and similar technologies.
https://rightsstatements.org/vocab/InC/1.0/
© Copyright 2025 American Association of Neurological Surgeons. All rights reserved, including those for text and data mining, AI training, and similar technologies.
https://rightsstatements.org/vocab/InC/1.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202412177316
https://urn.fi/URN:NBN:fi:oulu-202412177316
Tiivistelmä
Abstract
Objective:
Approximately 70%–80% of children born with myelomeningocele develop hydrocephalus and need CSF diversion, commonly a ventriculoperitoneal shunt (VPS) placement. The optimal timing of surgery is not known, but many centers delay VPS placement and perform it in a separate surgery to avoid shunt complications, mainly shunt contamination and infection. This systematic review and meta-analysis aimed to compare shunt-related complications between populations with VPS surgery performed either simultaneously with myelomeningocele closure or with delay.
Methods:
The authors searched MEDLINE (PubMed), Scopus, Web of Science, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews databases on December 15, 2022, and November 11, 2023, using a predefined search strategy. Randomized and nonrandomized trials of neonates undergoing postnatal myelomeningocele closure and VPS placement before the age of 29 days were included. Cases with prenatal myelomeningocele closure and hydrocephalus treatment other than a VPS were excluded. All studies were screened and assessed by two independent reviewers. The authors performed a meta-analysis pooling risk ratios (RRs) with a 95% CI using the random-effects model. The quality of studies was assessed using the Newcastle-Ottawa Scale.
Results:
After screening and a full-text review of 2099 database search results, 12 studies with a total number of 4894 patients were included. All studies were nonrandomized studies. Only 2 studies were ranked as good quality on the Newcastle-Ottawa Scale. No statistically significant differences were found between simultaneous and delayed shunt insertion in terms of shunt infection (RR 0.77, 95% CI 0.41–1.42); shunt revision (RR 0.49, 95% CI 0.19–1.30); overall mortality (RR 0.87, 95% CI 0.09–8.57); wound CSF leak (RR 0.20, 95% CI 0.03–1.23); or myelomeningocele wound dehiscence (RR 0.52, 95% CI 0.07–3.71). In the subgroup analysis of studies conducted in high-income countries, simultaneous shunting was superior to delayed shunting concerning shunt infection (RR 0.49, 95% CI 0.31–0.78) and shunt revision (RR 0.30, 95% CI 0.09–0.95).
Conclusions:
This systematic review and meta-analysis found no statistically significant differences in shunt-related complications between simultaneous and delayed VPS surgery in myelomeningocele-related hydrocephalus in neonates. The current literature does not support the common practice of delayed shunting or its alternative, simultaneous shunting.
Objective:
Approximately 70%–80% of children born with myelomeningocele develop hydrocephalus and need CSF diversion, commonly a ventriculoperitoneal shunt (VPS) placement. The optimal timing of surgery is not known, but many centers delay VPS placement and perform it in a separate surgery to avoid shunt complications, mainly shunt contamination and infection. This systematic review and meta-analysis aimed to compare shunt-related complications between populations with VPS surgery performed either simultaneously with myelomeningocele closure or with delay.
Methods:
The authors searched MEDLINE (PubMed), Scopus, Web of Science, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews databases on December 15, 2022, and November 11, 2023, using a predefined search strategy. Randomized and nonrandomized trials of neonates undergoing postnatal myelomeningocele closure and VPS placement before the age of 29 days were included. Cases with prenatal myelomeningocele closure and hydrocephalus treatment other than a VPS were excluded. All studies were screened and assessed by two independent reviewers. The authors performed a meta-analysis pooling risk ratios (RRs) with a 95% CI using the random-effects model. The quality of studies was assessed using the Newcastle-Ottawa Scale.
Results:
After screening and a full-text review of 2099 database search results, 12 studies with a total number of 4894 patients were included. All studies were nonrandomized studies. Only 2 studies were ranked as good quality on the Newcastle-Ottawa Scale. No statistically significant differences were found between simultaneous and delayed shunt insertion in terms of shunt infection (RR 0.77, 95% CI 0.41–1.42); shunt revision (RR 0.49, 95% CI 0.19–1.30); overall mortality (RR 0.87, 95% CI 0.09–8.57); wound CSF leak (RR 0.20, 95% CI 0.03–1.23); or myelomeningocele wound dehiscence (RR 0.52, 95% CI 0.07–3.71). In the subgroup analysis of studies conducted in high-income countries, simultaneous shunting was superior to delayed shunting concerning shunt infection (RR 0.49, 95% CI 0.31–0.78) and shunt revision (RR 0.30, 95% CI 0.09–0.95).
Conclusions:
This systematic review and meta-analysis found no statistically significant differences in shunt-related complications between simultaneous and delayed VPS surgery in myelomeningocele-related hydrocephalus in neonates. The current literature does not support the common practice of delayed shunting or its alternative, simultaneous shunting.
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