Significance of mucin-suspended tumor bud-like structures in colorectal cancer
Äijälä, Ville K; Sirniö, Päivi; Elomaa, Hanna; Karjalainen, Henna; Kastinen, Meeri; Tapiainen, Vilja V; Ahtiainen, Maarit; Helminen, Olli; Wirta, Erkki-Ville; Rintala, Jukka; Meriläinen, Sanna; Saarnio, Juha; Rautio, Tero; Seppälä, Toni T; Böhm, Jan; Mecklin, Jukka-Pekka; Tuomisto, Anne; Mäkinen, Markus J; Väyrynen, Juha P (2025-04-14)
Elsevier
14.04.2025
Ville K. Äijälä, Päivi Sirniö, Hanna Elomaa, Henna Karjalainen, Meeri Kastinen, Vilja V. Tapiainen, Maarit Ahtiainen, Olli Helminen, Erkki-Ville Wirta, Jukka Rintala, Sanna Meriläinen, Juha Saarnio, Tero Rautio, Toni T. Seppälä, Jan Böhm, Jukka-Pekka Mecklin, Anne Tuomisto, Markus J. Mäkinen, Juha P. Väyrynen, Significance of mucin-suspended tumor bud-like structures in colorectal cancer, Human Pathology, Volume 158, 2025, 105772, ISSN 0046-8177, https://doi.org/10.1016/j.humpath.2025.105772
https://creativecommons.org/licenses/by/4.0/
© 2025 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
https://creativecommons.org/licenses/by/4.0/
© 2025 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
https://creativecommons.org/licenses/by/4.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202504232853
https://urn.fi/URN:NBN:fi:oulu-202504232853
Tiivistelmä
Abstract
Tumor budding (TB) is an independent predictor of adverse prognosis in colorectal cancer (CRC), defined as clusters of fewer than 5 tumor cells at the invasive margin of cancer. According to the international consensus criteria (ITBCC), TB should be evaluated from the non-mucinous regions. However, some tumors also contain tumor bud-like structures within extracellular mucin pools, and the prognostic impact of these structures remains unclear. To assess this, we defined a modified tumor budding variable (TB-Muc), representing the highest number of tumor buds/bud-like structures observed in a hotspot (0.785 mm2) at the invasive margin, including extracellular mucin regions. We analyzed the prognostic significance of TB (ITBCC criteria) and TB-Muc in two CRC cohorts (N = 1876). TB-ITBCC was associated with advanced stage and lymphovascular invasion (p < 0.001) but also with shorter cancer-specific survival independent of other prognostic factors (Cohort 1: HR for high vs. low 1.99, 95 % CI 1.32–3.01, ptrend = 0.0007; Cohort 2: HR 1.35, 95 % CI 0.98–1.85, ptrend = 0.037). TB-Muc had a comparable independent association with shorter cancer-specific survival (Cohort 1: HR for high vs. low 1.77, 95 % CI 1.18–2.65, ptrend = 0.006; Cohort 2: HR 1.39, 95 % CI 1.02–1.89, ptrend = 0.019). Our results indicate that tumor bud-like structures in mucin do not provide additional prognostic value and should not be included in TB evaluation.
Tumor budding (TB) is an independent predictor of adverse prognosis in colorectal cancer (CRC), defined as clusters of fewer than 5 tumor cells at the invasive margin of cancer. According to the international consensus criteria (ITBCC), TB should be evaluated from the non-mucinous regions. However, some tumors also contain tumor bud-like structures within extracellular mucin pools, and the prognostic impact of these structures remains unclear. To assess this, we defined a modified tumor budding variable (TB-Muc), representing the highest number of tumor buds/bud-like structures observed in a hotspot (0.785 mm2) at the invasive margin, including extracellular mucin regions. We analyzed the prognostic significance of TB (ITBCC criteria) and TB-Muc in two CRC cohorts (N = 1876). TB-ITBCC was associated with advanced stage and lymphovascular invasion (p < 0.001) but also with shorter cancer-specific survival independent of other prognostic factors (Cohort 1: HR for high vs. low 1.99, 95 % CI 1.32–3.01, ptrend = 0.0007; Cohort 2: HR 1.35, 95 % CI 0.98–1.85, ptrend = 0.037). TB-Muc had a comparable independent association with shorter cancer-specific survival (Cohort 1: HR for high vs. low 1.77, 95 % CI 1.18–2.65, ptrend = 0.006; Cohort 2: HR 1.39, 95 % CI 1.02–1.89, ptrend = 0.019). Our results indicate that tumor bud-like structures in mucin do not provide additional prognostic value and should not be included in TB evaluation.
Kokoelmat
- Avoin saatavuus [37920]
Ellei muuten mainita, aineiston lisenssi on https://creativecommons.org/licenses/by/4.0/