Lower hemoglobin levels associate with higher baroreflex sensitivity and heart rate variability
Tapio, Joona; Kiviniemi, Antti M; Perkiömäki, Juha; Junttila, M Juhani; Huikuri, Heikki V; Ukkola, Olavi; Koivunen, Peppi; Tulppo, Mikko P (2023-08-25)
American Physiological Society
25.08.2023
Tapio, J., Kiviniemi, A. M., Perkiömäki, J., Junttila, M. J., Huikuri, H. V., Ukkola, O., Koivunen, P., & Tulppo, M. P. (2023). Lower hemoglobin levels associate with higher baroreflex sensitivity and heart rate variability. American Journal of Physiology-Heart and Circulatory Physiology, 325(4), H629–H634. https://doi.org/10.1152/ajpheart.00415.2023
https://rightsstatements.org/vocab/InC/1.0/
© 2023 the American Physiological Society.
https://rightsstatements.org/vocab/InC/1.0/
© 2023 the American Physiological Society.
https://rightsstatements.org/vocab/InC/1.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202504042411
https://urn.fi/URN:NBN:fi:oulu-202504042411
Tiivistelmä
Abstract
The aim of this study was to cross-sectionally examine whether hemoglobin (Hb) levels within the normal variation associate with heart rate variability (HRV) measures and baroreflex sensitivity (BRS). The study population included 733 Finnish subjects of the OPERA cohort (aged 41–59 yr, 53% males, 51.7% treated for hypertension) of whom HRV was measured from a standardized 45-min period and whose Hb levels were within the Finnish reference intervals. The low Hb tertile (mean Hb, 135 g/L) had an overall healthier metabolic profile compared with the high Hb tertile (mean Hb, 152 g/L). BRS was higher in the low Hb tertile compared with the high Hb tertile (P < 0.05). R-R interval (RRi) and standard deviation (SD) of the RRi (SDNN)index were the longest in the low Hb tertile regardless of posture. Of the spectral components of HRV, HF power was the highest in the low Hb tertile regardless of posture (P < 0.05). In a stepwise logistic regression model, BRS associated negatively with Hb levels after adjusting for covariates (B = −0.160 [−0.285; −0.035]). Similar associations were observed for SDNNindex when lying down (B = −0.105 [−0.207; −0.003]) and walking (B = −0.154 [−0.224; −0.083]). For HF power negative associations with Hb levels were observed when lying down (B = −0.110 [−0.180; −0.040]), sitting (B = −0.150 [−0.221; −0.079]), and in total analysis (B = −0.124 [−0.196; −0.053]). Overall, lower Hb levels associated independently with healthier cardiac autonomic function.
The aim of this study was to cross-sectionally examine whether hemoglobin (Hb) levels within the normal variation associate with heart rate variability (HRV) measures and baroreflex sensitivity (BRS). The study population included 733 Finnish subjects of the OPERA cohort (aged 41–59 yr, 53% males, 51.7% treated for hypertension) of whom HRV was measured from a standardized 45-min period and whose Hb levels were within the Finnish reference intervals. The low Hb tertile (mean Hb, 135 g/L) had an overall healthier metabolic profile compared with the high Hb tertile (mean Hb, 152 g/L). BRS was higher in the low Hb tertile compared with the high Hb tertile (P < 0.05). R-R interval (RRi) and standard deviation (SD) of the RRi (SDNN)index were the longest in the low Hb tertile regardless of posture. Of the spectral components of HRV, HF power was the highest in the low Hb tertile regardless of posture (P < 0.05). In a stepwise logistic regression model, BRS associated negatively with Hb levels after adjusting for covariates (B = −0.160 [−0.285; −0.035]). Similar associations were observed for SDNNindex when lying down (B = −0.105 [−0.207; −0.003]) and walking (B = −0.154 [−0.224; −0.083]). For HF power negative associations with Hb levels were observed when lying down (B = −0.110 [−0.180; −0.040]), sitting (B = −0.150 [−0.221; −0.079]), and in total analysis (B = −0.124 [−0.196; −0.053]). Overall, lower Hb levels associated independently with healthier cardiac autonomic function.
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