Assessing Aflatoxin Exposure in the United Arab Emirates (UAE): Biomonitoring AFM1 levels in Urine Samples and their Association with Dietary Habits
Elabed, Shahd; Khaled, Raghad; Farhat, Nada; Madkour, Mohamed; Mohammad Zadeh, Shima A; Shousha, Tamer; Taneera, Jalal; Semerjian, Lucy; Abass, Khaled (2025-01-25)
Elsevier
25.01.2025
Elabed, S., Khaled, R., Farhat, N., Madkour, M., Mohammad Zadeh, S. A., Shousha, T., Taneera, J., Semerjian, L., & Abass, K. (2025). Assessing aflatoxin exposure in the United Arab Emirates (UAE): Biomonitoring AFM1 levels in urine samples and their association with dietary habits. Environmental Toxicology and Pharmacology, 114, 104644. https://doi.org/10.1016/j.etap.2025.104644
https://creativecommons.org/licenses/by/4.0/
© 2025 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
https://creativecommons.org/licenses/by/4.0/
© 2025 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
https://creativecommons.org/licenses/by/4.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202501311413
https://urn.fi/URN:NBN:fi:oulu-202501311413
Tiivistelmä
Abstract
Background:
Aflatoxins, known for their carcinoginc properties and produced by Aspergillus fungi, pose a substantial threat to public health, particularly in regions with hot and humid climates, where individuals are exposed to these toxins through contaminated food. The primary objective of this study was to assess the extent of aflatoxin exposure in the Emirate of Sharjah employing Aflatoxin M1 (AFM1) as a biomarker in urine samples from adult participants. Furthermore, this study aimed to explore the relationship between dietary habits and AFM1 levels in order to establish a potential link.
Methods:
In a cross-sectional study design, a total of 144 adults (73 females and 71 males) were recruited for participation. The urine samples obtained from participants were subjected to analysis for AFM1 concentrations utilizing the enzyme-linked immunosorbent assay (ELISA) method. Additionally, structured questionnaires were administered to collect information on the dietary and lifestyle habits of the participants. To explore the relationship between dietary factors and AFM1 levels, various statistical analyses, including linear regression and the Mann-Whitney U test, were performed.
Results:
AFM1 was detected in 69 % of the samples under invstigation, wherein males exhibited a higher mean level (0.912 ng/mg creatinine) in comparison to females (0.676 ng/mg creatinine). The overall mean concentration of AFM1 was determined to be 0.792 ng/mg creatinine. It is worth noting that there was a significant correlation between rice consumption and heightened AFM1 exposure among males, while no such correlation was observed among females.
Conclusion:
This study conducted in the UAE provides novel perspectives on aflatoxin exposure, shedding light on the gender-specific correlation between rice consumption and aflatoxin levels among males. These findings hold significant implications for guiding public health interventions and underscore the pivotal role of ongoing surveillance and stringent food safety regulations in mitigating the hazards associated with aflatoxin contamination.
Background:
Aflatoxins, known for their carcinoginc properties and produced by Aspergillus fungi, pose a substantial threat to public health, particularly in regions with hot and humid climates, where individuals are exposed to these toxins through contaminated food. The primary objective of this study was to assess the extent of aflatoxin exposure in the Emirate of Sharjah employing Aflatoxin M1 (AFM1) as a biomarker in urine samples from adult participants. Furthermore, this study aimed to explore the relationship between dietary habits and AFM1 levels in order to establish a potential link.
Methods:
In a cross-sectional study design, a total of 144 adults (73 females and 71 males) were recruited for participation. The urine samples obtained from participants were subjected to analysis for AFM1 concentrations utilizing the enzyme-linked immunosorbent assay (ELISA) method. Additionally, structured questionnaires were administered to collect information on the dietary and lifestyle habits of the participants. To explore the relationship between dietary factors and AFM1 levels, various statistical analyses, including linear regression and the Mann-Whitney U test, were performed.
Results:
AFM1 was detected in 69 % of the samples under invstigation, wherein males exhibited a higher mean level (0.912 ng/mg creatinine) in comparison to females (0.676 ng/mg creatinine). The overall mean concentration of AFM1 was determined to be 0.792 ng/mg creatinine. It is worth noting that there was a significant correlation between rice consumption and heightened AFM1 exposure among males, while no such correlation was observed among females.
Conclusion:
This study conducted in the UAE provides novel perspectives on aflatoxin exposure, shedding light on the gender-specific correlation between rice consumption and aflatoxin levels among males. These findings hold significant implications for guiding public health interventions and underscore the pivotal role of ongoing surveillance and stringent food safety regulations in mitigating the hazards associated with aflatoxin contamination.
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