Histopathological risk assessment in multisite epithelial dysplasia: A meta-analysis
Ferraz, Daniel Lobato Ferreira; Dos Santos, Erison Santana; Pedroso, Caique Mariano; Silva, Brunno Santos de Freitas; Kujan, Omar; Salo, Tuula Anneli; Malki, Mohammed I; Juteau, Susanna; Vargas, Pablo Agustin; Lopes, Marcio Ajudarte; Santos-Silva, Alan Roger (2024-06-30)
John Wiley & Sons
30.06.2024
Ferraz, D. L. F., dos Santos, E. S., Pedroso, C. M., Silva, B. S. d. F., Kujan, O., Salo, T. A., Malki, M. I., Juteau, S., Vargas, P. A., Lopes, M. A., & Santos-Silva, A. R. (2024). Histopathological risk assessment in multisite epithelial dysplasia: A meta-analysis. Oral Diseases, 30, 4821–4829. https://doi.org/10.1111/odi.15052
https://rightsstatements.org/vocab/InC/1.0/
© 2024 Wiley Periodicals LLC. This is the peer reviewed version of the following article: Ferraz, D. L. F., dos Santos, E. S., Pedroso, C. M., Silva, B. S. d. F., Kujan, O., Salo, T. A., Malki, M. I., Juteau, S., Vargas, P. A., Lopes, M. A., & Santos-Silva, A. R. (2024). Histopathological risk assessment in multisite epithelial dysplasia: A meta-analysis. Oral Diseases, 30, 4821–4829, which has been published in final form at https://doi.org/10.1111/odi.15052. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
https://rightsstatements.org/vocab/InC/1.0/
© 2024 Wiley Periodicals LLC. This is the peer reviewed version of the following article: Ferraz, D. L. F., dos Santos, E. S., Pedroso, C. M., Silva, B. S. d. F., Kujan, O., Salo, T. A., Malki, M. I., Juteau, S., Vargas, P. A., Lopes, M. A., & Santos-Silva, A. R. (2024). Histopathological risk assessment in multisite epithelial dysplasia: A meta-analysis. Oral Diseases, 30, 4821–4829, which has been published in final form at https://doi.org/10.1111/odi.15052. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
https://rightsstatements.org/vocab/InC/1.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202412137259
https://urn.fi/URN:NBN:fi:oulu-202412137259
Tiivistelmä
Abstract
Objective:
Histopathological grading of oral epithelial dysplasia (OED) is the current standard for stratifying cancer progression risk but is associated with subjectivity and variability. This problem is not commonly seen regarding the grading of epithelial dysplasia in other sites. This systematic review aims to compare grading systems for oral, anal, penile, and cervical epithelial dysplasia to determine their predictive accuracy for recurrence and malignant transformation (MT) outcomes.
Methods:
The review protocol was registered in PROSPERO (CRD42023403035) and was reported according to the PRISMA checklist. A comprehensive search was performed in the main databases and gray literature. The risk of bias in individual studies was analyzed using the Joanna Briggs Institute checklist for each study design.
Results:
Forty-six studies were deemed eligible and included in this systematic review, of which 45 were included in the quantitative analysis. Meta-analysis revealed that the binary system demonstrated a higher predictive ability for MT/recurrence of OED compared to multilevel systems. Higher predictive accuracy of MT was also observed for binary grading systems in anal intraepithelial neoplasia.
Conclusions:
No significant difference was found between the current grading systems of epithelial dysplasia in different body parts. However, binary grading systems have shown better clinical outcomes.
Objective:
Histopathological grading of oral epithelial dysplasia (OED) is the current standard for stratifying cancer progression risk but is associated with subjectivity and variability. This problem is not commonly seen regarding the grading of epithelial dysplasia in other sites. This systematic review aims to compare grading systems for oral, anal, penile, and cervical epithelial dysplasia to determine their predictive accuracy for recurrence and malignant transformation (MT) outcomes.
Methods:
The review protocol was registered in PROSPERO (CRD42023403035) and was reported according to the PRISMA checklist. A comprehensive search was performed in the main databases and gray literature. The risk of bias in individual studies was analyzed using the Joanna Briggs Institute checklist for each study design.
Results:
Forty-six studies were deemed eligible and included in this systematic review, of which 45 were included in the quantitative analysis. Meta-analysis revealed that the binary system demonstrated a higher predictive ability for MT/recurrence of OED compared to multilevel systems. Higher predictive accuracy of MT was also observed for binary grading systems in anal intraepithelial neoplasia.
Conclusions:
No significant difference was found between the current grading systems of epithelial dysplasia in different body parts. However, binary grading systems have shown better clinical outcomes.
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