Large-Scale Population-Based Studies of Blood Metabolome and Brain Health
Pausova, Zdenka; Sliz, Eeva (2024-03-21)
Avaa tiedosto
Sisältö avataan julkiseksi: 21.03.2025
Springer
21.03.2024
Pausova, Z., Sliz, E. (2024). Large-Scale Population-Based Studies of Blood Metabolome and Brain Health. In: Paus, T., Brook, J.R., Keyes, K., Pausova, Z. (eds) Principles and Advances in Population Neuroscience. Current Topics in Behavioral Neurosciences, vol 68. Springer, Cham. https://doi.org/10.1007/7854_2024_463
https://rightsstatements.org/vocab/InC/1.0/
© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG. This is a post-peer-review, pre-copyedit version of an article published in Principles and Advances in Population Neuroscience. The final authenticated version is available online at: https://doi.org/10.1007/7854_2024_463
https://rightsstatements.org/vocab/InC/1.0/
© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG. This is a post-peer-review, pre-copyedit version of an article published in Principles and Advances in Population Neuroscience. The final authenticated version is available online at: https://doi.org/10.1007/7854_2024_463
https://rightsstatements.org/vocab/InC/1.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202411296972
https://urn.fi/URN:NBN:fi:oulu-202411296972
Tiivistelmä
Abstract
Metabolomics technologies enable the quantification of multiple metabolomic measures simultaneously, which provides novel insights into molecular aspects of human health and disease. In large-scale, population-based studies, blood is often the preferred biospecimen. Circulating metabolome may relate to brain health either by affecting or reflecting brain metabolism. Peripheral metabolites may act at or cross the blood–brain barrier and, subsequently, influence brain metabolism, or they may reflect brain metabolism if similar pathways are engaged. Peripheral metabolites may also include those penetrating the circulation from the brain, indicating, for example, brain damage. Most brain health-related metabolomics studies have been conducted in the context of neurodegenerative disorders and cognition, but some studies have also focused on neuroimaging markers of these disorders. Moreover, several metabolomics studies of neurodevelopmental disorders have been performed. Here, we provide a brief background on the types of blood metabolites commonly assessed, and we review the literature describing the relationships between human blood metabolome (n > 50 metabolites) and brain health reported in large-scale studies (n > 500 individuals).
Metabolomics technologies enable the quantification of multiple metabolomic measures simultaneously, which provides novel insights into molecular aspects of human health and disease. In large-scale, population-based studies, blood is often the preferred biospecimen. Circulating metabolome may relate to brain health either by affecting or reflecting brain metabolism. Peripheral metabolites may act at or cross the blood–brain barrier and, subsequently, influence brain metabolism, or they may reflect brain metabolism if similar pathways are engaged. Peripheral metabolites may also include those penetrating the circulation from the brain, indicating, for example, brain damage. Most brain health-related metabolomics studies have been conducted in the context of neurodegenerative disorders and cognition, but some studies have also focused on neuroimaging markers of these disorders. Moreover, several metabolomics studies of neurodevelopmental disorders have been performed. Here, we provide a brief background on the types of blood metabolites commonly assessed, and we review the literature describing the relationships between human blood metabolome (n > 50 metabolites) and brain health reported in large-scale studies (n > 500 individuals).
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