Compact time-domain diffuse optics system based on CMOS technologies for fast acquisitions of heartbeat-induced absorption changes
Avanzi, Elisabetta; Talala, Tuomo; Sieno, Laura Di; Mora, Alberto Dalla; Nissinen, Ilkka; Nissinen, Jan
IEEE
E. Avanzi, T. Talala, L. Di Sieno, A. Dalla Mora, I. Nissinen and J. Nissinen, "Compact Time-Domain Diffuse Optics System Based on CMOS Technologies for Fast Acquisitions of Heartbeat-Induced Absorption Changes," in IEEE Sensors Journal, vol. 24, no. 23, pp. 38912-38921, 1 Dec.1, 2024, doi: 10.1109/JSEN.2024.3480323
https://creativecommons.org/licenses/by/4.0/
© 2024 The Authors. This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/
https://creativecommons.org/licenses/by/4.0/
© 2024 The Authors. This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/
https://creativecommons.org/licenses/by/4.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202411086664
https://urn.fi/URN:NBN:fi:oulu-202411086664
Tiivistelmä
Abstract
This work introduces a novel compact Time-Domain Diffuse Optics (TD-DO) system based on CMOS integrated circuits for being potentially used in non-invasive tissue characterization and physiological monitoring. The system incorporates a ~800 nm emitting laser diode and a 256-channel Single-Photon Avalanche Diode (SPAD) line sensor, offering high-throughput data acquisition. It offers remarkable capabilities for non-invasive investigations of diffusive media for biological and non-biological applications. To enhance system performance, an alignment method of the TD curves based on cross-correlation maximization is proposed and validated under internationally agreed protocols, such as MEDPHOT and nEUROPt. Finally, fast oscillations in optical properties corresponding to the heartbeat have been detected, showcasing the potential of the system for real-time physiological tracking. The results display the potential of the proposed compact TD-DO system, paving the way for the implementation of wearable instruments capable of non-invasively tracking fast physiological dynamics with high accuracy and robustness.
This work introduces a novel compact Time-Domain Diffuse Optics (TD-DO) system based on CMOS integrated circuits for being potentially used in non-invasive tissue characterization and physiological monitoring. The system incorporates a ~800 nm emitting laser diode and a 256-channel Single-Photon Avalanche Diode (SPAD) line sensor, offering high-throughput data acquisition. It offers remarkable capabilities for non-invasive investigations of diffusive media for biological and non-biological applications. To enhance system performance, an alignment method of the TD curves based on cross-correlation maximization is proposed and validated under internationally agreed protocols, such as MEDPHOT and nEUROPt. Finally, fast oscillations in optical properties corresponding to the heartbeat have been detected, showcasing the potential of the system for real-time physiological tracking. The results display the potential of the proposed compact TD-DO system, paving the way for the implementation of wearable instruments capable of non-invasively tracking fast physiological dynamics with high accuracy and robustness.
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