Enhancing diaphragmatic defect repair and regeneration: How biomaterials leading the way to progress?
Farahani, Mojtaba; Gnatowski, Przemyslaw; Najafloo, Raziyeh; Navaei, Tina; Pilat, Edyta; Kucinska-Lipka, Justyna; Saeb, Mohammad Reza; Mozafari, Masoud (2024-01-21)
John Wiley & Sons
21.01.2024
M. Farahani, P. Gnatowski, R. Najafloo, T. Navaei, E. Piłat, J. Kucińska-Lipka, M. R. Saeb, M. Mozafari, BMEMat 2024, 2(3), e12070. https://doi.org/10.1002/bmm2.12070
https://creativecommons.org/licenses/by/4.0/
© 2024 The Authors. BMEMat published by John Wiley & Sons Australia, Ltd on behalf of Shandong University. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
https://creativecommons.org/licenses/by/4.0/
© 2024 The Authors. BMEMat published by John Wiley & Sons Australia, Ltd on behalf of Shandong University. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
https://creativecommons.org/licenses/by/4.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202410076201
https://urn.fi/URN:NBN:fi:oulu-202410076201
Tiivistelmä
Abstract
Physicians encounter significant challenges in dealing with large diaphragmatic defects in both pediatric and adult populations. Diaphragmatic hernias, such as Morgagni, Bochdalek, and Hiatus hernias, can result in congenital lesions that are often undiagnosed until the appearance of symptoms (bleeding, anemia, and acid reflux). Therefore, substantial potential exists for developing tissue-engineered constructs as novel therapeutic options in clinics. Recent research indicates promising mid-term performance for both natural and synthetic materials. However, studies exploring their application in diaphragm regeneration are limited and remain in the early research stages. Additionally, further investigation is required to address the constraints in human tissue supply for clinical implementation. This article comprehensively reviews the role of biomaterials in diaphragmatic tissue repair and regeneration. It emphasizes biomaterials, including biomimetic polymers used in technological solutions. This summary will enable researchers to critically assess the capability of existing natural biomaterials as essential tissue-engineered patches for clinical use.
Physicians encounter significant challenges in dealing with large diaphragmatic defects in both pediatric and adult populations. Diaphragmatic hernias, such as Morgagni, Bochdalek, and Hiatus hernias, can result in congenital lesions that are often undiagnosed until the appearance of symptoms (bleeding, anemia, and acid reflux). Therefore, substantial potential exists for developing tissue-engineered constructs as novel therapeutic options in clinics. Recent research indicates promising mid-term performance for both natural and synthetic materials. However, studies exploring their application in diaphragm regeneration are limited and remain in the early research stages. Additionally, further investigation is required to address the constraints in human tissue supply for clinical implementation. This article comprehensively reviews the role of biomaterials in diaphragmatic tissue repair and regeneration. It emphasizes biomaterials, including biomimetic polymers used in technological solutions. This summary will enable researchers to critically assess the capability of existing natural biomaterials as essential tissue-engineered patches for clinical use.
Kokoelmat
- Avoin saatavuus [38865]
Ellei muuten mainita, aineiston lisenssi on https://creativecommons.org/licenses/by/4.0/