Early-pregnancy BMI, maternal gestational weight gain, and asthma and allergic diseases in children
Ojwang', Vincent; Nwaru, Bright I; Hanna-Mari, Takkinen; Heli, Tapanainen; Kaila, Minna; Ahonen, Suvi; Niemelä, Onni; Haapala, Anna-Maija; Ilonen, Jorma; Toppari, Jorma; Hyöty, Heikki; Veijola, Riitta; Knip, Mikael; Virtanen, Suvi M (2024-09-16)
Ojwang', Vincent
Nwaru, Bright I
Hanna-Mari, Takkinen
Heli, Tapanainen
Kaila, Minna
Ahonen, Suvi
Niemelä, Onni
Haapala, Anna-Maija
Ilonen, Jorma
Toppari, Jorma
Hyöty, Heikki
Veijola, Riitta
Knip, Mikael
Virtanen, Suvi M
John Wiley & Sons
16.09.2024
Ojwang’ V, Nwaru BI, Hanna-Mari T, et al. Early-pregnancy BMI, maternal gestational weight gain, and asthma and allergic diseases in children. Pediatr Allergy Immunol. 2024; 35:e14240. doi:10.1111/pai.14240
https://creativecommons.org/licenses/by/4.0/
© 2024 The Author(s). Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
https://creativecommons.org/licenses/by/4.0/
© 2024 The Author(s). Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
https://creativecommons.org/licenses/by/4.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202409185942
https://urn.fi/URN:NBN:fi:oulu-202409185942
Tiivistelmä
Abstract
Background:
Association of early pregnancy body mass index (BMI) and maternal gestational weight gain (GWG), and asthma and allergic disease in children is unclear.
Methods:
We analyzed data from 3176 mother–child pairs in a prospective birth cohort study. Maternal anthropometric measurements in the first and last antenatal clinic visits were obtained through post-delivery questionnaires to calculate early pregnancy BMI and maternal GWG. Asthma and allergic diseases in children by the age of 5 years was assessed using a validated questionnaire. Furthermore, serum samples were analyzed for IgE antibodies to eight allergens. We applied Cox proportional hazards and logistic regression analyses to estimate the association of early pregnancy BMI and maternal GWG (as continuous variables and categorized into quarters), and asthma, atopic eczema, atopic sensitization, and allergic rhinitis in children.
Results:
Neither early pregnancy BMI nor maternal GWG was associated with asthma and allergic disease in children when analyzed as continuous variables. However, compared to the first quarter of GWG (a rate <0.32 kg/week), mothers in the third quarter (rate 0.42–0.52 kg/week) had children with significantly higher odds of developing atopic eczema (adjusted OR 1.49, 95% CI [1.13–1.96]) by 5 years of age.
Conclusion:
Association of early pregnancy BMI and maternal GWG, and asthma and allergic disease in children, is inconsistent. High maternal GWG may be associated with increased odds of atopic eczema.
Background:
Association of early pregnancy body mass index (BMI) and maternal gestational weight gain (GWG), and asthma and allergic disease in children is unclear.
Methods:
We analyzed data from 3176 mother–child pairs in a prospective birth cohort study. Maternal anthropometric measurements in the first and last antenatal clinic visits were obtained through post-delivery questionnaires to calculate early pregnancy BMI and maternal GWG. Asthma and allergic diseases in children by the age of 5 years was assessed using a validated questionnaire. Furthermore, serum samples were analyzed for IgE antibodies to eight allergens. We applied Cox proportional hazards and logistic regression analyses to estimate the association of early pregnancy BMI and maternal GWG (as continuous variables and categorized into quarters), and asthma, atopic eczema, atopic sensitization, and allergic rhinitis in children.
Results:
Neither early pregnancy BMI nor maternal GWG was associated with asthma and allergic disease in children when analyzed as continuous variables. However, compared to the first quarter of GWG (a rate <0.32 kg/week), mothers in the third quarter (rate 0.42–0.52 kg/week) had children with significantly higher odds of developing atopic eczema (adjusted OR 1.49, 95% CI [1.13–1.96]) by 5 years of age.
Conclusion:
Association of early pregnancy BMI and maternal GWG, and asthma and allergic disease in children, is inconsistent. High maternal GWG may be associated with increased odds of atopic eczema.
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