Higher haemoglobin levels are associated with impaired periodontal status
Tapiola, Atte; Tapio, Joona; Vähänikkilä, Hannu; Tegelberg, Paula; Ylöstalo, Pekka; Koivunen, Peppi (2024-06-14)
Tapiola, Atte
Tapio, Joona
Vähänikkilä, Hannu
Tegelberg, Paula
Ylöstalo, Pekka
Koivunen, Peppi
Wiley-Blackwell
14.06.2024
Tapiola, A., Tapio, J., Vähänikkilä, H., Tegelberg, P., Ylöstalo, P., & Koivunen, P. (2024). Higher haemoglobin levels are associated with impaired periodontal status. Journal of Clinical Periodontology, 51(9), 1168–1177. https://doi.org/10.1111/jcpe.14030
https://creativecommons.org/licenses/by-nc/4.0/
© 2024 The Author(s). Journal of Clinical Periodontology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes
https://creativecommons.org/licenses/by-nc/4.0/
© 2024 The Author(s). Journal of Clinical Periodontology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes
https://creativecommons.org/licenses/by-nc/4.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202406174647
https://urn.fi/URN:NBN:fi:oulu-202406174647
Tiivistelmä
Abstract
Aim:
Cellular oxygen sensing mechanisms have been linked to periodontal condition, and levels of haemoglobin (Hb) (the main carrier of oxygen) can be used as a surrogate measure for hypoxia. We aimed to examine relations between Hb levels and key periodontal health parameters in a general population.
Materials and Methods:
The population comprised 1711 (47% male) subjects from the Northern Finland Birth Cohort 1966, for whom an oral health examination was carried out at 46 years of age and whose Hb levels were within the Finnish reference values. Relative risks (RRs) were estimated using Poisson regression models.
Results:
The low-Hb tertile (mean Hb 133 g/L) had healthier anthropometric, metabolic and periodontal health parameters than the high-Hb tertile (mean Hb 151 g/L). Multivariable regression models adjusted for risk factors showed Hb levels to be positively associated with alveolar bone loss (ABL) and periodontal pocket depth (PPD), although the associations were weaker after adjustment for key metabolic parameters and were strongly influenced by smoking status.
Conclusions:
Hb levels within the normal variation are positively associated with PPD and ABL. The association between Hb levels and periodontal condition appeared to be more complex than had previously been anticipated.
Aim:
Cellular oxygen sensing mechanisms have been linked to periodontal condition, and levels of haemoglobin (Hb) (the main carrier of oxygen) can be used as a surrogate measure for hypoxia. We aimed to examine relations between Hb levels and key periodontal health parameters in a general population.
Materials and Methods:
The population comprised 1711 (47% male) subjects from the Northern Finland Birth Cohort 1966, for whom an oral health examination was carried out at 46 years of age and whose Hb levels were within the Finnish reference values. Relative risks (RRs) were estimated using Poisson regression models.
Results:
The low-Hb tertile (mean Hb 133 g/L) had healthier anthropometric, metabolic and periodontal health parameters than the high-Hb tertile (mean Hb 151 g/L). Multivariable regression models adjusted for risk factors showed Hb levels to be positively associated with alveolar bone loss (ABL) and periodontal pocket depth (PPD), although the associations were weaker after adjustment for key metabolic parameters and were strongly influenced by smoking status.
Conclusions:
Hb levels within the normal variation are positively associated with PPD and ABL. The association between Hb levels and periodontal condition appeared to be more complex than had previously been anticipated.
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