TWINGEN: protocol for an observational clinical biobank recall and biomarker cohort study to identify Finnish individuals with high risk of Alzheimer's disease
Vuoksimaa, Eero; Saari, Toni T; Aaltonen, Aino; Aaltonen, Sari; Herukka, Sanna-Kaisa; Iso-Markku, Paula; Kokkola, Tarja; Kyttälä, Aija; Kärkkäinen, Sari; Liedes, Hilkka; Ollikainen, Miina; Palviainen, Teemu; Ruotsalainen, Ilona; Toivola, Auli; Urjansson, Mia; Vasankari, Tommi; Vähä-Ypyä, Henri; Forsberg, Markus M; Hiltunen, Mikko; Jalanko, Anu; Kälviäinen, Reetta; Kuopio, Teijo; Lähteenmäki, Jaakko; Nyberg, Pia; Männikkö, Minna; Serpi, Raisa; Siltanen, Sanna; Palotie, Aarno; Kaprio, Jaakko; Runz, Heiko; Julkunen, Valtteri; FinnGen (2024-06-12)
Vuoksimaa, Eero
Saari, Toni T
Aaltonen, Aino
Aaltonen, Sari
Herukka, Sanna-Kaisa
Iso-Markku, Paula
Kokkola, Tarja
Kyttälä, Aija
Kärkkäinen, Sari
Liedes, Hilkka
Ollikainen, Miina
Palviainen, Teemu
Ruotsalainen, Ilona
Toivola, Auli
Urjansson, Mia
Vasankari, Tommi
Vähä-Ypyä, Henri
Forsberg, Markus M
Hiltunen, Mikko
Jalanko, Anu
Kälviäinen, Reetta
Kuopio, Teijo
Lähteenmäki, Jaakko
Nyberg, Pia
Männikkö, Minna
Serpi, Raisa
Siltanen, Sanna
Palotie, Aarno
Kaprio, Jaakko
Runz, Heiko
Julkunen, Valtteri
FinnGen
BMJ Publishing Group
12.06.2024
Vuoksimaa, E., Saari, T. T., Aaltonen, A., Aaltonen, S., Herukka, S.-K., Iso-Markku, P., Kokkola, T., Kyttälä, A., Kärkkäinen, S., Liedes, H., Ollikainen, M., Palviainen, T., Ruotsalainen, I., Toivola, A., Urjansson, M., Vasankari, T., Vähä-Ypyä, H., Forsberg, M. M., Hiltunen, M., … Julkunen, V. (2024). TWINGEN: Protocol for an observational clinical biobank recall and biomarker cohort study to identify Finnish individuals with high risk of Alzheimer’s disease. BMJ Open, 14(6), e081947. https://doi.org/10.1136/bmjopen-2023-081947
https://creativecommons.org/licenses/by/4.0/
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.
https://creativecommons.org/licenses/by/4.0/
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.
https://creativecommons.org/licenses/by/4.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202406144546
https://urn.fi/URN:NBN:fi:oulu-202406144546
Tiivistelmä
Abstract
Introduction:
A better understanding of the earliest stages of Alzheimer’s disease (AD) could expedite the development or administration of treatments. Large population biobanks hold the promise to identify individuals at an elevated risk of AD and related dementias based on health registry information. Here, we establish the protocol for an observational clinical recall and biomarker study called TWINGEN with the aim to identify individuals at high risk of AD by assessing cognition, health and AD-related biomarkers. Suitable candidates were identified and invited to participate in the new study among THL Biobank donors according to TWINGEN study criteria.
Methods and analysis:
A multi-centre study (n=800) to obtain blood-based biomarkers, telephone-administered and web-based memory and cognitive parameters, questionnaire information on lifestyle, health and psychological factors, and accelerometer data for measures of physical activity, sedentary behaviour and sleep. A subcohort is being asked to participate in an in-person neuropsychological assessment (n=200) and wear an Oura ring (n=50). All participants in the TWINGEN study have genome-wide genotyping data and up to 48 years of follow-up data from the population-based older Finnish Twin Cohort (FTC) study of the University of Helsinki. The data collected in TWINGEN will be returned to THL Biobank from where it can later be requested for other biobank studies such as FinnGen that supported TWINGEN.
Ethics and dissemination:
This recall study consists of FTC/THL Biobank/FinnGen participants whose data were acquired in accordance with the Finnish Biobank Act. The recruitment protocols followed the biobank protocols approved by Finnish Medicines Agency. The TWINGEN study plan was approved by the Ethics Committee of Hospital District of Helsinki and Uusimaa (number 16831/2022). THL Biobank approved the research plan with the permission no: THLBB2022_83.
Introduction:
A better understanding of the earliest stages of Alzheimer’s disease (AD) could expedite the development or administration of treatments. Large population biobanks hold the promise to identify individuals at an elevated risk of AD and related dementias based on health registry information. Here, we establish the protocol for an observational clinical recall and biomarker study called TWINGEN with the aim to identify individuals at high risk of AD by assessing cognition, health and AD-related biomarkers. Suitable candidates were identified and invited to participate in the new study among THL Biobank donors according to TWINGEN study criteria.
Methods and analysis:
A multi-centre study (n=800) to obtain blood-based biomarkers, telephone-administered and web-based memory and cognitive parameters, questionnaire information on lifestyle, health and psychological factors, and accelerometer data for measures of physical activity, sedentary behaviour and sleep. A subcohort is being asked to participate in an in-person neuropsychological assessment (n=200) and wear an Oura ring (n=50). All participants in the TWINGEN study have genome-wide genotyping data and up to 48 years of follow-up data from the population-based older Finnish Twin Cohort (FTC) study of the University of Helsinki. The data collected in TWINGEN will be returned to THL Biobank from where it can later be requested for other biobank studies such as FinnGen that supported TWINGEN.
Ethics and dissemination:
This recall study consists of FTC/THL Biobank/FinnGen participants whose data were acquired in accordance with the Finnish Biobank Act. The recruitment protocols followed the biobank protocols approved by Finnish Medicines Agency. The TWINGEN study plan was approved by the Ethics Committee of Hospital District of Helsinki and Uusimaa (number 16831/2022). THL Biobank approved the research plan with the permission no: THLBB2022_83.
Kokoelmat
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