Polarization-based optical interference approach for differential diagnosis of benign and malignant tumours
Sdobnov, Anton; Ushenko, Volodimir A.; Trifonyuk, Liliya; Dubolazov, Olexander V.; Ushenko, Yuriy A.; Ushenko, Alexander G.; Soltys, Irina V.; Gantyuk, Vyacheslav K.; Bykov, Alexander; Meglinski, Igor (2023-09-07)
Avaa tiedosto
Sisältö avataan julkiseksi: 07.09.2025
Elsevier
07.09.2023
Sdobnov, A., Ushenko, V. A., Trifonyuk, L., Dubolazov, O. V., Ushenko, Y. A., Ushenko, A. G., Soltys, I. V., Gantyuk, V. K., Bykov, A., & Meglinski, I. (2023). Polarization-based optical interference approach for differential diagnosis of benign and malignant tumours. Optics and Lasers in Engineering, 171, 107806. https://doi.org/10.1016/j.optlaseng.2023.107806
https://creativecommons.org/licenses/by-nc-nd/4.0/
© 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
https://creativecommons.org/licenses/by-nc-nd/4.0/
© 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
https://creativecommons.org/licenses/by-nc-nd/4.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202405294074
https://urn.fi/URN:NBN:fi:oulu-202405294074
Tiivistelmä
Abstract
The polarization-based optical interference approach is expanded for an express differentiation between prostate adenocarcinoma with different grades and Gleason scores. The approach is founded on evaluation of local contrast of polarized interference patterns originated by a superposition of reference laser beam and interference of light transmitted through the tissue sample placed in the image plane. The observed polarization-based optical interference patterns are linked directly to the morphology of the biological tissue under investigation. The polarization patterns obtained for three sets of histological sections of the prostate tumour biopsy samples are further processed with the statistical moments of 1st to 4th order. The developed approach is implemented for assessment of histological sections of the prostate tumour tissues with high, moderately and poorly differentiated adenocarcinoma. The application of the developed polarization-based optical interference approach demonstrates a high (> 90%) level of accuracy.
The polarization-based optical interference approach is expanded for an express differentiation between prostate adenocarcinoma with different grades and Gleason scores. The approach is founded on evaluation of local contrast of polarized interference patterns originated by a superposition of reference laser beam and interference of light transmitted through the tissue sample placed in the image plane. The observed polarization-based optical interference patterns are linked directly to the morphology of the biological tissue under investigation. The polarization patterns obtained for three sets of histological sections of the prostate tumour biopsy samples are further processed with the statistical moments of 1st to 4th order. The developed approach is implemented for assessment of histological sections of the prostate tumour tissues with high, moderately and poorly differentiated adenocarcinoma. The application of the developed polarization-based optical interference approach demonstrates a high (> 90%) level of accuracy.
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