Myocardium tissue alterations in acute cardiac attack and respiratory arrest evaluated by polarized light
Kuzmin, E. A.; Balkivskiy, A. S.; Koryashkina, T. G.; Kartashkina, N. L.; Yatskovskiy, A. N.; Meglinski, I.; Piavchenko, G. A. (2023-08-11)
SPIE
11.08.2023
E. A. Kuzmin, A. S. Balkivskiy, T. G. Koryashkina, N. L. Kartashkina, A. N. Yatskovskiy, I. Meglinski, and G. A. Piavchenko "Myocardium tissue alterations in acute cardiac attack and respiratory arrest evaluated by polarized light", Proc. SPIE 12629, Emerging Technologies for Cell and Tissue Characterization II, 1262907 (11 August 2023); https://doi.org/10.1117/12.2671005
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Copyright 2023 Society of Photo‑Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, and modification of the contents of the publication are prohibited.
https://rightsstatements.org/vocab/InC/1.0/
Copyright 2023 Society of Photo‑Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, and modification of the contents of the publication are prohibited.
https://rightsstatements.org/vocab/InC/1.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202405294053
https://urn.fi/URN:NBN:fi:oulu-202405294053
Tiivistelmä
Abstract
Many pathologies leading to the death of the organism are tied to the cessation of cardiac or respiratory activity. In the present study, we studied the microscopic structure of the myocardium of male Wistar rats under conditions of acute cardiac and respiratory arrest. Unstained histological sections of the myocardium are examined with a polarizing microscope for the length of the sarcomere, A- and I-discs measurements. The results of the study showed that the length of the sarcomere during respiratory arrest and cardiac attack significantly decreases due to the length of the I-disc, especially in acute cardiac attack. Correlation-regression analysis showed sharp decrease of correlation in acute respiratory arrest, reaching extremely low values in cardiac attack. The study allows assessing ultrastructural changes in the myocardium and forms the basis for diagnosing acute heart pathology with the machine learning and automated analysis.
Many pathologies leading to the death of the organism are tied to the cessation of cardiac or respiratory activity. In the present study, we studied the microscopic structure of the myocardium of male Wistar rats under conditions of acute cardiac and respiratory arrest. Unstained histological sections of the myocardium are examined with a polarizing microscope for the length of the sarcomere, A- and I-discs measurements. The results of the study showed that the length of the sarcomere during respiratory arrest and cardiac attack significantly decreases due to the length of the I-disc, especially in acute cardiac attack. Correlation-regression analysis showed sharp decrease of correlation in acute respiratory arrest, reaching extremely low values in cardiac attack. The study allows assessing ultrastructural changes in the myocardium and forms the basis for diagnosing acute heart pathology with the machine learning and automated analysis.
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