Low-grade inflammation from prenatal period to age 6-8 years in a Vitamin D trial
Hauta-Alus, Helena H; Rosendahl, Jenni; Holmlund-Suila, Elisa M; Valkama, Saara M; Enlund-Cerullo, Maria; Nurhonen, Markku; Kajantie, Eero; Mäkitie, Outi; Andersson, Sture (2024-01-15)
Springer
15.01.2024
Hauta-alus, H.H., Rosendahl, J., Holmlund-Suila, E.M. et al. Low-grade inflammation from prenatal period to age 6–8 years in a Vitamin D trial. Pediatr Res 95, 1578–1586 (2024). https://doi.org/10.1038/s41390-024-03019-4
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© The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
https://creativecommons.org/licenses/by/4.0/
© The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202405143471
https://urn.fi/URN:NBN:fi:oulu-202405143471
Tiivistelmä
Abstract
Background:
Low-grade systemic inflammation measured as high sensitivity C-reactive protein (hs-CRP) has been associated with non-communicable disease risk. We assessed whether prenatal inflammation and early-childhood vitamin D are associated with inflammation until age 6–8.
Methods:
We analyzed blood hs-CRP and 25-hydroxy vitamin D [25(OH)D] in pregnancy, at birth from umbilical cord blood (UCB), from offspring at ages 1, 2, and 6–8 years in the Vitamin D Intervention in Infants (VIDI) study. VIDI was a randomized-controlled trial of vitamin D supplementation of 10 μg/day or 30 μg/day from age 2 weeks until 2 years in 975 infants recruited in 2013–14, with follow-up at age 6–8 in 2019–21 (n = 283).
Results:
Pregnancy hs-CRP was associated with UCB hs-CRP (r = 0.18, p < 0.001) but not independently with childhood hs-CRP (Estimate [95% CI] 0.04 [<−0.00, 0.09]). Higher UCB hs-CRP was associated independently with higher hs-CRP until 6–8 years (0.20 [0.12, 0.29]). Infant vitamin D dose had no effect on longitudinal hs-CRP (6–8 years, 0.11 [−0.04, 0.25]). Childhood 25(OH)D were associated positively with hs-CRP until age 6–8 (0.01 [>0.00, 0.01]).
Conclusion:
Our results indicate that in children, inflammation, assessed by hs-CRP, persists from birth until 6–8 years. We observed positive associations between 25(OH)D and hs-CRP in vitamin D-sufficient children.
Impact:
-High sensitivity C-reactive protein (hs-CRP) concentrations tract from birth to age 8 years
-Our novel finding suggests a long-lasting pro-inflammatory phenotype in the child
-Higher vitamin D concentration - but not dose – is associated with higher childhood hs-CRP
-Chronic disease risk related to inflammation may in part originate from the prenatal period or early childhood
-Further studies are needed to investigate the effects of inflammation on long-term clinical health outcomes
Background:
Low-grade systemic inflammation measured as high sensitivity C-reactive protein (hs-CRP) has been associated with non-communicable disease risk. We assessed whether prenatal inflammation and early-childhood vitamin D are associated with inflammation until age 6–8.
Methods:
We analyzed blood hs-CRP and 25-hydroxy vitamin D [25(OH)D] in pregnancy, at birth from umbilical cord blood (UCB), from offspring at ages 1, 2, and 6–8 years in the Vitamin D Intervention in Infants (VIDI) study. VIDI was a randomized-controlled trial of vitamin D supplementation of 10 μg/day or 30 μg/day from age 2 weeks until 2 years in 975 infants recruited in 2013–14, with follow-up at age 6–8 in 2019–21 (n = 283).
Results:
Pregnancy hs-CRP was associated with UCB hs-CRP (r = 0.18, p < 0.001) but not independently with childhood hs-CRP (Estimate [95% CI] 0.04 [<−0.00, 0.09]). Higher UCB hs-CRP was associated independently with higher hs-CRP until 6–8 years (0.20 [0.12, 0.29]). Infant vitamin D dose had no effect on longitudinal hs-CRP (6–8 years, 0.11 [−0.04, 0.25]). Childhood 25(OH)D were associated positively with hs-CRP until age 6–8 (0.01 [>0.00, 0.01]).
Conclusion:
Our results indicate that in children, inflammation, assessed by hs-CRP, persists from birth until 6–8 years. We observed positive associations between 25(OH)D and hs-CRP in vitamin D-sufficient children.
Impact:
-High sensitivity C-reactive protein (hs-CRP) concentrations tract from birth to age 8 years
-Our novel finding suggests a long-lasting pro-inflammatory phenotype in the child
-Higher vitamin D concentration - but not dose – is associated with higher childhood hs-CRP
-Chronic disease risk related to inflammation may in part originate from the prenatal period or early childhood
-Further studies are needed to investigate the effects of inflammation on long-term clinical health outcomes
Kokoelmat
- Avoin saatavuus [37957]
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