Near-Infrared Spectroscopic Study Towards Clinical Radiotherapy Treatment Monitoring
Karthikeyan, Priya; Ferdinando, Hany; Korhonen, Vesa; Honka, Ulriika; Lohela, Jesse; Inget, Kalle; Karhula, Sakari; Nikkinen, Juha; Myllylä, Teemu (2024-05-05)
Springer
05.05.2024
Karthikeyan, P. et al. (2024). Near-Infrared Spectroscopic Study Towards Clinical Radiotherapy Treatment Monitoring. In: Särestöniemi, M., et al. Digital Health and Wireless Solutions. NCDHWS 2024. Communications in Computer and Information Science, vol 2083. Springer, Cham. https://doi.org/10.1007/978-3-031-59080-1_17
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© 2024 The Author(s). This chapter is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. The images or other third party material in this chapter are included in the chapter’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the chapter’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
https://creativecommons.org/licenses/by/4.0/
© 2024 The Author(s). This chapter is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. The images or other third party material in this chapter are included in the chapter’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the chapter’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
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Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202405133355
https://urn.fi/URN:NBN:fi:oulu-202405133355
Tiivistelmä
Abstract
This study used near-infrared spectroscopy to monitor dynamic spectral effects to radiotherapy aiming to monitor spectral response for clinical radiotherapy. Twenty-four patients with total fractions of 96 measurements were measured to evaluate the dynamic spectral status of radiotherapy response. Dynamic responses from absorbance measurement were found to be associated with effects of induced radiation to skin and it linearly correlates to the dose given. Whereas significantly no response was found in ex vivo samples. A spectrometer was used in near infrared range between 650 nm and 1100 nm wavelength in absorbance mode. The absorbance spectral dynamics were measured using one light source-detector probe attached to the forehead in human patients and chicken samples to compare their responses to irradiation. The absorbance measurements of the forehead (skin) show absorbance increase throughout the spectra during irradiation in patients and confirmed with repeatability whereas in corresponding irradiation of ex vivo chicken samples, no absorbance changes were detected. Since spectral range of 650 nm–950 nm is dominantly affected by hemodynamical changes in tissue this indicates the oxygenation of blood in patients is strongly affected by irradiation. Furthermore, the irradiation caused absorbance changes also between 950 nm to 1100 nm range which is dominated by water in tissue, however in ex vivo chicken no visible effects of irradiation were detected in this range either.
This study used near-infrared spectroscopy to monitor dynamic spectral effects to radiotherapy aiming to monitor spectral response for clinical radiotherapy. Twenty-four patients with total fractions of 96 measurements were measured to evaluate the dynamic spectral status of radiotherapy response. Dynamic responses from absorbance measurement were found to be associated with effects of induced radiation to skin and it linearly correlates to the dose given. Whereas significantly no response was found in ex vivo samples. A spectrometer was used in near infrared range between 650 nm and 1100 nm wavelength in absorbance mode. The absorbance spectral dynamics were measured using one light source-detector probe attached to the forehead in human patients and chicken samples to compare their responses to irradiation. The absorbance measurements of the forehead (skin) show absorbance increase throughout the spectra during irradiation in patients and confirmed with repeatability whereas in corresponding irradiation of ex vivo chicken samples, no absorbance changes were detected. Since spectral range of 650 nm–950 nm is dominantly affected by hemodynamical changes in tissue this indicates the oxygenation of blood in patients is strongly affected by irradiation. Furthermore, the irradiation caused absorbance changes also between 950 nm to 1100 nm range which is dominated by water in tissue, however in ex vivo chicken no visible effects of irradiation were detected in this range either.
Kokoelmat
- Avoin saatavuus [37743]
Ellei muuten mainita, aineiston lisenssi on https://creativecommons.org/licenses/by/4.0/