Association of respiratory virus types with clinical features in bronchiolitis: Implications for virus testing strategies. A systematic review and meta-analysis
Ambrożej, Dominika; Orzołek, Izabela; Makrinioti, Heidi; Castro-Rodriguez, Jose A; Camargo, Carlos A; Hasegawa, Kohei; Papadopoulos, Nikolaos G; Gern, James E; Nino, Gustavo; Vicente Ribeiro Ferreira da Silva Filho, Luiz; Takeyama, Aya; Üzüm, Özlem; Adamiec, Aleksander; Ruszczyński, Marek; Jartti, Tuomas; Feleszko, Wojciech (2023-09-17)
Elsevier
17.09.2023
Dominika Ambrożej, Izabela Orzołek, Heidi Makrinioti, Jose A. Castro-Rodriguez, Carlos A. Camargo Jr., Kohei Hasegawa, Nikolaos G. Papadopoulos, James E. Gern, Gustavo Nino, Luiz Vicente Ribeiro Ferreira da Silva Filho, Aya Takeyama, Özlem Üzüm, Aleksander Adamiec, Marek Ruszczyński, Tuomas Jartti, Wojciech Feleszko, Association of respiratory virus types with clinical features in bronchiolitis: Implications for virus testing strategies. A systematic review and meta-analysis, Paediatric Respiratory Reviews, Volume 49, 2024, Pages 34-42, ISSN 1526-0542, https://doi.org/10.1016/j.prrv.2023.09.003
https://creativecommons.org/licenses/by/4.0/
© 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
https://creativecommons.org/licenses/by/4.0/
© 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
https://creativecommons.org/licenses/by/4.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202404152719
https://urn.fi/URN:NBN:fi:oulu-202404152719
Tiivistelmä
Abstract
Background:
Bronchiolitis is a leading cause of infant hospitalization, linked to respiratory syncytial virus (RSV) and rhinovirus (RV). Guidelines lack specific viral testing for bronchiolitis management. To establish effective management strategies, it is crucial to assess whether specific respiratory virus types are correlated with distinct examination features.
Methods:
Through a systematic search of three databases, 21 studies were qualitatively analyzed, with 18 used for meta-analysis. Various outcomes like wheezing on auscultation, fever, atopic traits, and infection severity were evaluated.
Results:
RSV-positive bronchiolitis was associated with a higher need for oxygen supplementation (OR 1.78, 95% CI 1.04–3.02) in 5 studies, while RV-positive bronchiolitis was more frequently linked to personal history of eczema (OR 0.60, 95% CI 0.41–0.88) in 6 studies. No significant differences were observed in the other outcomes examined.
Conclusions:
Bronchiolitis caused by RSV or RV presents with similar clinical features. Despite the associations between RSV-positive bronchiolitis and need for oxygen supplementation, and RV-positive bronchiolitis and a history of eczema, our study shows that viral etiology of bronchiolitis cannot be determined solely based on clinical presentation.
Tailored management strategies, informed by accurate viral testing, seem crucial in clinical practice for enhancing patient outcomes in severe bronchiolitis.
Background:
Bronchiolitis is a leading cause of infant hospitalization, linked to respiratory syncytial virus (RSV) and rhinovirus (RV). Guidelines lack specific viral testing for bronchiolitis management. To establish effective management strategies, it is crucial to assess whether specific respiratory virus types are correlated with distinct examination features.
Methods:
Through a systematic search of three databases, 21 studies were qualitatively analyzed, with 18 used for meta-analysis. Various outcomes like wheezing on auscultation, fever, atopic traits, and infection severity were evaluated.
Results:
RSV-positive bronchiolitis was associated with a higher need for oxygen supplementation (OR 1.78, 95% CI 1.04–3.02) in 5 studies, while RV-positive bronchiolitis was more frequently linked to personal history of eczema (OR 0.60, 95% CI 0.41–0.88) in 6 studies. No significant differences were observed in the other outcomes examined.
Conclusions:
Bronchiolitis caused by RSV or RV presents with similar clinical features. Despite the associations between RSV-positive bronchiolitis and need for oxygen supplementation, and RV-positive bronchiolitis and a history of eczema, our study shows that viral etiology of bronchiolitis cannot be determined solely based on clinical presentation.
Tailored management strategies, informed by accurate viral testing, seem crucial in clinical practice for enhancing patient outcomes in severe bronchiolitis.
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