Preventing Biofilm Formation and Encrustation on Urinary Implants: (Bio)coatings and Tissue Engineering
Buchholz, Noor; De Graaf, Petra; De la Cruz, Julia E.; Kram, Wolfgang; Skovorodkin, Ilya; Soria, Federico; Vainio, Seppo (2022-08-21)
Springer
21.08.2022
Buchholz, N. et al. (2022). Preventing Biofilm Formation and Encrustation on Urinary Implants: (Bio)coatings and Tissue Engineering. In: Soria, F., Rako, D., de Graaf, P. (eds) Urinary Stents. Springer, Cham. https://doi.org/10.1007/978-3-031-04484-7_33
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© 2022 The Author(s). This chapter is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. The images or other third party material in this chapter are included in the chapter's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the chapter's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
https://creativecommons.org/licenses/by/4.0/
© 2022 The Author(s). This chapter is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. The images or other third party material in this chapter are included in the chapter's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the chapter's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
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Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202401241433
https://urn.fi/URN:NBN:fi:oulu-202401241433
Tiivistelmä
Abstract
Even though urinary stents and catheters have been commonly applied in medicine for several decades and still are constantly being modified and optimized, their structure and performance still requires further improvement. A major drawback of urinary implants is the deposition of organic and non-organic substances on their surface leading to biofilm formation resulting in encrustations, blockages, and infections. Promising research lines are stent coatings with antibodies, enzymes and various bioactive compounds. We will also discuss the possibility of making urinary implants more “tissue friendly” by designing biomimetic surfaces. Finally, in accordance with the paradigm “repair or regrow” we will touch on tissue engineering approaches to replace artificial urinary implants by those generated in vitro or in vivo from homologous tissue. We summarised modern biological approaches to improve the structure, function and performance of urinary stents. Some have been already applied in urinary stent production whilst others have been tested in the field of vascular stents, such as antibody or biomimetic coating. Bioengineering approaches aiming at the generation of complete analogs of damaged urinary tissue from autologous patient-derived cells represent a more futuristic outlook. Nevertheless, we hope that the rapid development of advanced multidisciplinary research platforms in modern biomedicine will make these approaches feasible in the near future.
Even though urinary stents and catheters have been commonly applied in medicine for several decades and still are constantly being modified and optimized, their structure and performance still requires further improvement. A major drawback of urinary implants is the deposition of organic and non-organic substances on their surface leading to biofilm formation resulting in encrustations, blockages, and infections. Promising research lines are stent coatings with antibodies, enzymes and various bioactive compounds. We will also discuss the possibility of making urinary implants more “tissue friendly” by designing biomimetic surfaces. Finally, in accordance with the paradigm “repair or regrow” we will touch on tissue engineering approaches to replace artificial urinary implants by those generated in vitro or in vivo from homologous tissue. We summarised modern biological approaches to improve the structure, function and performance of urinary stents. Some have been already applied in urinary stent production whilst others have been tested in the field of vascular stents, such as antibody or biomimetic coating. Bioengineering approaches aiming at the generation of complete analogs of damaged urinary tissue from autologous patient-derived cells represent a more futuristic outlook. Nevertheless, we hope that the rapid development of advanced multidisciplinary research platforms in modern biomedicine will make these approaches feasible in the near future.
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