A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation
Li, Shaobo; Spitz, Natalia; Ghantous, Akram; Abrishamcar, Sarina; Reimann, Brigitte; Marques, Irene; Silver, Matt J; Aguilar-Lacasaña, Sofía; Kitaba, Negusse; Rezwan, Faisal I; Röder, Stefan; Sirignano, Lea; Tuhkanen, Johanna; Mancano, Giulia; Sharp, Gemma C; Metayer, Catherine; Morimoto, Libby; Stein, Dan J; Zar, Heather J; Alfano, Rossella; Nawrot, Tim; Wang, Congrong; Kajantie, Eero; Keikkala, Elina; Mustaniemi, Sanna; Ronkainen, Justiina; Sebert, Sylvain; Silva, Wnurinham; Vääräsmäki, Marja; Jaddoe, Vincent W V; Bernstein, Robin M; Prentice, Andrew M; Cosin-Tomas, Marta; Dwyer, Terence; Håberg, Siri Eldevik; Herceg, Zdenko; Magnus, Maria C; Munthe-Kaas, Monica Cheng; Page, Christian M; Völker, Maja; Gilles, Maria; Send, Tabea; Witt, Stephanie; Zillich, Lea; Gagliardi, Luigi; Richiardi, Lorenzo; Czamara, Darina; Räikkönen, Katri; Chatzi, Lida; Vafeiadi, Marina; Arshad, S Hasan; Ewart, Susan; Plusquin, Michelle; Felix, Janine F; Moore, Sophie E; Vrijheid, Martine; Holloway, John W; Karmaus, Wilfried; Herberth, Gunda; Zenclussen, Ana; Streit, Fabian; Lahti, Jari; Hüls, Anke; Hoang, Thanh T; London, Stephanie J; Wiemels, Joseph L (2024-01-09)
Li, Shaobo
Spitz, Natalia
Ghantous, Akram
Abrishamcar, Sarina
Reimann, Brigitte
Marques, Irene
Silver, Matt J
Aguilar-Lacasaña, Sofía
Kitaba, Negusse
Rezwan, Faisal I
Röder, Stefan
Sirignano, Lea
Tuhkanen, Johanna
Mancano, Giulia
Sharp, Gemma C
Metayer, Catherine
Morimoto, Libby
Stein, Dan J
Zar, Heather J
Alfano, Rossella
Nawrot, Tim
Wang, Congrong
Kajantie, Eero
Keikkala, Elina
Mustaniemi, Sanna
Ronkainen, Justiina
Sebert, Sylvain
Silva, Wnurinham
Vääräsmäki, Marja
Jaddoe, Vincent W V
Bernstein, Robin M
Prentice, Andrew M
Cosin-Tomas, Marta
Dwyer, Terence
Håberg, Siri Eldevik
Herceg, Zdenko
Magnus, Maria C
Munthe-Kaas, Monica Cheng
Page, Christian M
Völker, Maja
Gilles, Maria
Send, Tabea
Witt, Stephanie
Zillich, Lea
Gagliardi, Luigi
Richiardi, Lorenzo
Czamara, Darina
Räikkönen, Katri
Chatzi, Lida
Vafeiadi, Marina
Arshad, S Hasan
Ewart, Susan
Plusquin, Michelle
Felix, Janine F
Moore, Sophie E
Vrijheid, Martine
Holloway, John W
Karmaus, Wilfried
Herberth, Gunda
Zenclussen, Ana
Streit, Fabian
Lahti, Jari
Hüls, Anke
Hoang, Thanh T
London, Stephanie J
Wiemels, Joseph L
Springer
09.01.2024
Li, S., Spitz, N., Ghantous, A. et al. A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation. Commun Biol 7, 66 (2024). https://doi.org/10.1038/s42003-023-05698-x
https://creativecommons.org/licenses/by/4.0/
© The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
https://creativecommons.org/licenses/by/4.0/
© The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
https://creativecommons.org/licenses/by/4.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202401221397
https://urn.fi/URN:NBN:fi:oulu-202401221397
Tiivistelmä
Abstract
Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA methylation alterations. We investigated birth order with Illumina DNA methylation array data in each of 16 birth cohorts (8164 newborns) with European, African, and Latino ancestries from the Pregnancy and Childhood Epigenetics Consortium. Meta-analyzed data demonstrated systematic DNA methylation variation in 341 CpGs (FDR adjusted P < 0.05) and 1107 regions. Forty CpGs were located within known quantitative trait loci for gene expression traits in blood, and trait enrichment analysis suggested a strong association with immune-related, transcriptional control, and blood pressure regulation phenotypes. Decreasing fertility rates worldwide with the concomitant increased proportion of first-born children highlights a potential reflection of birth order-related epigenomic states on changing disease incidence trends.
Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA methylation alterations. We investigated birth order with Illumina DNA methylation array data in each of 16 birth cohorts (8164 newborns) with European, African, and Latino ancestries from the Pregnancy and Childhood Epigenetics Consortium. Meta-analyzed data demonstrated systematic DNA methylation variation in 341 CpGs (FDR adjusted P < 0.05) and 1107 regions. Forty CpGs were located within known quantitative trait loci for gene expression traits in blood, and trait enrichment analysis suggested a strong association with immune-related, transcriptional control, and blood pressure regulation phenotypes. Decreasing fertility rates worldwide with the concomitant increased proportion of first-born children highlights a potential reflection of birth order-related epigenomic states on changing disease incidence trends.
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