Effect of sleep deprivation and NREM sleep stage on physiological brain pulsations
Helakari, Heta; Järvelä, Matti; Väyrynen, Tommi; Tuunanen, Johanna; Piispala, Johanna; Kallio, Mika; Ebrahimi, Seyed Mohsen; Poltojainen, Valter; Kananen, Janne; Elabasy, Ahmed; Huotari, Niko; Raitamaa, Lauri; Tuovinen, Timo; Korhonen, Vesa; Nedergaard, Maiken; Kiviniemi, Vesa (2023-12-01)
Frontiers Media
01.12.2023
Helakari H, Järvelä M, Väyrynen T, Tuunanen J, Piispala J, Kallio M, Ebrahimi SM, Poltojainen V, Kananen J, Elabasy A, Huotari N, Raitamaa L, Tuovinen T, Korhonen V, Nedergaard M and Kiviniemi V (2023) Effect of sleep deprivation and NREM sleep stage on physiological brain pulsations. Front. Neurosci. 17:1275184. doi: 10.3389/fnins.2023.1275184
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© 2023 Helakari, Järvelä, Väyrynen, Tuunanen, Piispala, Kallio, Ebrahimi, Poltojainen, Kananen, Elabasy, Huotari, Raitamaa, Tuovinen, Korhonen, Nedergaard and Kiviniemi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
https://creativecommons.org/licenses/by/4.0/
© 2023 Helakari, Järvelä, Väyrynen, Tuunanen, Piispala, Kallio, Ebrahimi, Poltojainen, Kananen, Elabasy, Huotari, Raitamaa, Tuovinen, Korhonen, Nedergaard and Kiviniemi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
https://creativecommons.org/licenses/by/4.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202401091156
https://urn.fi/URN:NBN:fi:oulu-202401091156
Tiivistelmä
Abstract
Introduction:
Sleep increases brain fluid transport and the power of pulsations driving the fluids. We investigated how sleep deprivation or electrophysiologically different stages of non-rapid-eye-movement (NREM) sleep affect the human brain pulsations.
Methods:
Fast functional magnetic resonance imaging (fMRI) was performed in healthy subjects (n = 23) with synchronous electroencephalography (EEG), that was used to verify arousal states (awake, N1 and N2 sleep). Cardiorespiratory rates were verified with physiological monitoring. Spectral power analysis assessed the strength, and spectral entropy assessed the stability of the pulsations.
Results:
In N1 sleep, the power of vasomotor (VLF < 0.1 Hz), but not cardiorespiratory pulsations, intensified after sleep deprived vs. non-sleep deprived subjects. The power of all three pulsations increased as a function of arousal state (N2 > N1 > awake) encompassing brain tissue in both sleep stages, but extra-axial CSF spaces only in N2 sleep. Spectral entropy of full band and respiratory pulsations decreased most in N2 sleep stage, while cardiac spectral entropy increased in ventricles.
Discussion:
In summary, the sleep deprivation and sleep depth, both increase the power and harmonize the spectral content of human brain pulsations.
Introduction:
Sleep increases brain fluid transport and the power of pulsations driving the fluids. We investigated how sleep deprivation or electrophysiologically different stages of non-rapid-eye-movement (NREM) sleep affect the human brain pulsations.
Methods:
Fast functional magnetic resonance imaging (fMRI) was performed in healthy subjects (n = 23) with synchronous electroencephalography (EEG), that was used to verify arousal states (awake, N1 and N2 sleep). Cardiorespiratory rates were verified with physiological monitoring. Spectral power analysis assessed the strength, and spectral entropy assessed the stability of the pulsations.
Results:
In N1 sleep, the power of vasomotor (VLF < 0.1 Hz), but not cardiorespiratory pulsations, intensified after sleep deprived vs. non-sleep deprived subjects. The power of all three pulsations increased as a function of arousal state (N2 > N1 > awake) encompassing brain tissue in both sleep stages, but extra-axial CSF spaces only in N2 sleep. Spectral entropy of full band and respiratory pulsations decreased most in N2 sleep stage, while cardiac spectral entropy increased in ventricles.
Discussion:
In summary, the sleep deprivation and sleep depth, both increase the power and harmonize the spectral content of human brain pulsations.
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