Protein target highlights in CASP15: Analysis of models by structure providers
Alexander, Leila T; Durairaj, Janani; Kryshtafovych, Andriy; Abriata, Luciano A; Bayo, Yusupha; Bhabha, Gira; Breyton, Cécile; Caulton, Simon G; Chen, James; Degroux, Séraphine; Ekiert, Damian C; Erlandsen, Benedikte S; Freddolino, Peter L; Gilzer, Dominic; Greening, Chris; Grimes, Jonathan M; Grinter, Rhys; Gurusaran, Manickam; Hartmann, Marcus D; Hitchman, Charlie J; Keown, Jeremy R; Kropp, Ashleigh; Kursula, Petri; Lovering, Andrew L; Lemaitre, Bruno; Lia, Andrea; Liu, Shiheng; Logotheti, Maria; Lu, Shuze; Markússon, Sigurbjörn; Miller, Mitchell D; Minasov, George; Niemann, Hartmut H; Opazo, Felipe; Phillips, George N; Davies, Owen R; Rommelaere, Samuel; Rosas-Lemus, Monica; Roversi, Pietro; Satchell, Karla; Smith, Nathan; Wilson, Mark A; Wu, Kuan-Lin; Xia, Xian; Xiao, Han; Zhang, Wenhua; Zhou, Z Hong; Fidelis, Krzysztof; Topf, Maya; Moult, John; Schwede, Torsten (2023-11-23)
Wiley-Blackwell
23.11.2023
Alexander LT, Durairaj J, Kryshtafovych A, et al. Protein target highlights in CASP15: Analysis of models by structure providers. Proteins. 2023; 91(12): 1571-1599. doi:10.1002/prot.26545
https://creativecommons.org/licenses/by/4.0/
© 2023 The Authors. Proteins: Structure, Function, and Bioinformatics published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
https://creativecommons.org/licenses/by/4.0/
© 2023 The Authors. Proteins: Structure, Function, and Bioinformatics published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
https://creativecommons.org/licenses/by/4.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202401081100
https://urn.fi/URN:NBN:fi:oulu-202401081100
Tiivistelmä
Abstract
We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology.
We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology.
Kokoelmat
- Avoin saatavuus [38841]
Ellei muuten mainita, aineiston lisenssi on https://creativecommons.org/licenses/by/4.0/