Insights into the Notch signaling pathway in degenerative musculoskeletal disorders: Mechanisms and perspectives
Liu, Gaoming; Wei, Jun; Xiao, Wenfeng; Xie, Wenqing; Ru, Qin; Chen, Lin; Wu, Yuxiang; Mobasheri, Ali; Li, Yusheng (2023-11-17)
Elsevier
17.11.2023
Gaoming Liu, Jun Wei, Wenfeng Xiao, Wenqing Xie, Qin Ru, Lin Chen, Yuxiang Wu, Ali Mobasheri, Yusheng Li, Insights into the Notch signaling pathway in degenerative musculoskeletal disorders: Mechanisms and perspectives, Biomedicine & Pharmacotherapy, Volume 169, 2023, 115884, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2023.115884
https://creativecommons.org/licenses/by/4.0/
© 2023 The Authors. Published by Elsevier Masson SAS. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
https://creativecommons.org/licenses/by/4.0/
© 2023 The Authors. Published by Elsevier Masson SAS. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
https://creativecommons.org/licenses/by/4.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202401051072
https://urn.fi/URN:NBN:fi:oulu-202401051072
Tiivistelmä
Abstract
Degenerative musculoskeletal disorders are a group of age-related diseases of the locomotive system that severely affects the patient's ability to work and cause adverse sequalae such as fractures and even death. The incidence and prevalence of degenerative musculoskeletal disorders is rising owing to the aging of the world’s population. The Notch signaling pathway, which is expressed in almost all organ systems, extensively regulates cell proliferation and differentiation as well as cellular fate. Notch signaling shows increased activity in degenerative musculoskeletal disorders and retards the progression of degeneration to some extent. The review focuses on four major degenerative musculoskeletal disorders (osteoarthritis, intervertebral disc degeneration, osteoporosis, and sarcopenia) and summarizes the pathophysiological functions of Notch signaling in these disorders, especially its role in stem/progenitor cells in each disorder. Finally, a conclusion will be presented to explore the research and application of the perspectives on Notch signaling in degenerative musculoskeletal disorders.
Degenerative musculoskeletal disorders are a group of age-related diseases of the locomotive system that severely affects the patient's ability to work and cause adverse sequalae such as fractures and even death. The incidence and prevalence of degenerative musculoskeletal disorders is rising owing to the aging of the world’s population. The Notch signaling pathway, which is expressed in almost all organ systems, extensively regulates cell proliferation and differentiation as well as cellular fate. Notch signaling shows increased activity in degenerative musculoskeletal disorders and retards the progression of degeneration to some extent. The review focuses on four major degenerative musculoskeletal disorders (osteoarthritis, intervertebral disc degeneration, osteoporosis, and sarcopenia) and summarizes the pathophysiological functions of Notch signaling in these disorders, especially its role in stem/progenitor cells in each disorder. Finally, a conclusion will be presented to explore the research and application of the perspectives on Notch signaling in degenerative musculoskeletal disorders.
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