High anticholinergic burden and hyposalivation and xerostomia in the elderly
Stenbäck, Juuso; Tiisanoja, Antti; Syrjälä, Anna-Maija; Komulainen, Kaija; Hartikainen, Sirpa; Ylöstalo, Pekka (2023-01-10)
Taylor & Francis
10.01.2023
Juuso Stenbäck, Antti Tiisanoja, Anna-Maija Syrjälä, Kaija Komulainen, Sirpa Hartikainen & Pekka Ylöstalo (2023) High anticholinergic burden and hyposalivation and xerostomia in the elderly, Acta Odontologica Scandinavica, 81:6, 436-442, DOI: 10.1080/00016357.2023.2166105
https://creativecommons.org/licenses/by-nc/4.0/
This is an Accepted Manuscript version of the following article, accepted for publication in Acta odontologica scandinavica. Juuso Stenbäck, Antti Tiisanoja, Anna-Maija Syrjälä, Kaija Komulainen, Sirpa Hartikainen & Pekka Ylöstalo (2023) High anticholinergic burden and hyposalivation and xerostomia in the elderly, Acta Odontologica Scandinavica, 81:6, 436-442, DOI: 10.1080/00016357.2023.2166105. It is deposited under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
https://creativecommons.org/licenses/by-nc/4.0/
This is an Accepted Manuscript version of the following article, accepted for publication in Acta odontologica scandinavica. Juuso Stenbäck, Antti Tiisanoja, Anna-Maija Syrjälä, Kaija Komulainen, Sirpa Hartikainen & Pekka Ylöstalo (2023) High anticholinergic burden and hyposalivation and xerostomia in the elderly, Acta Odontologica Scandinavica, 81:6, 436-442, DOI: 10.1080/00016357.2023.2166105. It is deposited under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
https://creativecommons.org/licenses/by-nc/4.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202312193928
https://urn.fi/URN:NBN:fi:oulu-202312193928
Tiivistelmä
Abstract
Objective:
The aim was to study the association between high anticholinergic burden and hyposalivation and xerostomia among older people.
Background:
Anticholinergic drugs have been shown to cause xerostomia and hyposalivation. Yet there are few studies on the association between anticholinergic burden and hyposalivation and xerostomia in the elderly.
Material and Methods:
The study population consisted of community-dwelling older people (n = 321, mean age 81.6 years) from the Oral health GeMS study. Participants provided salivary samples and xerostomia was determined with a questionnaire. The baseline data were collected by interviews, oral clinical examinations and from patient records. Each participant’s anticholinergic burden was determined by eight anticholinergic scales. Poisson regression models with robust error variance were used to estimate relative risks (RR) with a 95% confidence interval (CI).
Results:
RRs of high anticholinergic burden in anticholinergic scales for xerostomia (multiple symptoms) ranged from 1.02 to 1.68; for low unstimulated salivary flow (≤0.1 mL/min) from 1.47 to 1.67; and for low stimulated salivary flow (≤0.7 mL/min) from 0.99 to 2.07. A high anticholinergic burden according to seven out of eight scales was associated (p < .05) with hyposalivation or xerostomia.
Conclusions:
A high anticholinergic burden was associated more strongly with hyposalivation (both unstimulated and stimulated) than with xerostomia.
Objective:
The aim was to study the association between high anticholinergic burden and hyposalivation and xerostomia among older people.
Background:
Anticholinergic drugs have been shown to cause xerostomia and hyposalivation. Yet there are few studies on the association between anticholinergic burden and hyposalivation and xerostomia in the elderly.
Material and Methods:
The study population consisted of community-dwelling older people (n = 321, mean age 81.6 years) from the Oral health GeMS study. Participants provided salivary samples and xerostomia was determined with a questionnaire. The baseline data were collected by interviews, oral clinical examinations and from patient records. Each participant’s anticholinergic burden was determined by eight anticholinergic scales. Poisson regression models with robust error variance were used to estimate relative risks (RR) with a 95% confidence interval (CI).
Results:
RRs of high anticholinergic burden in anticholinergic scales for xerostomia (multiple symptoms) ranged from 1.02 to 1.68; for low unstimulated salivary flow (≤0.1 mL/min) from 1.47 to 1.67; and for low stimulated salivary flow (≤0.7 mL/min) from 0.99 to 2.07. A high anticholinergic burden according to seven out of eight scales was associated (p < .05) with hyposalivation or xerostomia.
Conclusions:
A high anticholinergic burden was associated more strongly with hyposalivation (both unstimulated and stimulated) than with xerostomia.
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