Identity matters: cancer stem cells and tumour plasticity in head and neck squamous cell carcinoma
Salem, Abdelhakim; Salo, Tuula (2023-02-06)
Published by Cambridge University Press in association with the Clinical and Biomedical Computing Unit of the University of Cambridge School of Clinical Medicine
06.02.2023
Salem, A., & Salo, T. (2023). Identity matters: Cancer stem cells and tumour plasticity in head and neck squamous cell carcinoma. Expert Reviews in Molecular Medicine, 25, E8. doi:10.1017/erm.2023.4
https://rightsstatements.org/vocab/InC/1.0/
This article has been published in a revised form in Expert reviews in molecular medicine https://doi.org/10.1017/erm.2023.4. This version is free to view and download for private research and study only. Not for re-distribution or re-use. © The Author(s), 2023. Published by Cambridge University Press.
https://rightsstatements.org/vocab/InC/1.0/
This article has been published in a revised form in Expert reviews in molecular medicine https://doi.org/10.1017/erm.2023.4. This version is free to view and download for private research and study only. Not for re-distribution or re-use. © The Author(s), 2023. Published by Cambridge University Press.
https://rightsstatements.org/vocab/InC/1.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202312133740
https://urn.fi/URN:NBN:fi:oulu-202312133740
Tiivistelmä
Abstract
Head and neck squamous cell carcinoma (HNSCC) represents frequent yet aggressive tumours that encompass complex ecosystems of stromal and neoplastic components including a dynamic population of cancer stem cells (CSCs). Recently, research in the field of CSCs has gained increased momentum owing in part to their role in tumourigenicity, metastasis, therapy resistance and relapse. We provide herein a comprehensive assessment of the latest progress in comprehending CSC plasticity, including newly discovered influencing factors and their possible application in HNSCC. We further discuss the dynamic interplay of CSCs within tumour microenvironment considering our evolving appreciation of the contribution of oral microbiota and the pressing need for relevant models depicting their features. In sum, CSCs and tumour plasticity represent an exciting and expanding battleground with great implications for cancer therapy that are only beginning to be appreciated in head and neck oncology.
Head and neck squamous cell carcinoma (HNSCC) represents frequent yet aggressive tumours that encompass complex ecosystems of stromal and neoplastic components including a dynamic population of cancer stem cells (CSCs). Recently, research in the field of CSCs has gained increased momentum owing in part to their role in tumourigenicity, metastasis, therapy resistance and relapse. We provide herein a comprehensive assessment of the latest progress in comprehending CSC plasticity, including newly discovered influencing factors and their possible application in HNSCC. We further discuss the dynamic interplay of CSCs within tumour microenvironment considering our evolving appreciation of the contribution of oral microbiota and the pressing need for relevant models depicting their features. In sum, CSCs and tumour plasticity represent an exciting and expanding battleground with great implications for cancer therapy that are only beginning to be appreciated in head and neck oncology.
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