Perinatal and Other Risk Factors for Common Infections in Infancy: A Prospective Cohort Study
Hyvönen, Sanni; Tapiainen, Terhi; Pokka, Tytti; Solasaari, Terhi; Korpela, Katri; de Vos, Willem M.; Salonen, Anne; Kolho, Kaija-Leena (2023-09-14)
Lippincott williams & wilkins
14.09.2023
Hyvönen, Sanni MD; Tapiainen, Terhi MD, Ph; Pokka, Tytti MS; Solasaari, Terhi MD; Korpela, Katri PhD; de Vos, Willem M. PhD; Salonen, Anne PhD; Kolho, Kaija-Leena MD, PhD. Perinatal and Other Risk Factors for Common Infections in Infancy: A Prospective Cohort Study. The Pediatric Infectious Disease Journal 42(12):p e447-e453, December 2023. | DOI: 10.1097/INF.0000000000004112
https://creativecommons.org/licenses/by/4.0/
© 2023 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
https://creativecommons.org/licenses/by/4.0/
© 2023 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
https://creativecommons.org/licenses/by/4.0/
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:oulu-202312113616
https://urn.fi/URN:NBN:fi:oulu-202312113616
Tiivistelmä
Abstract
Objective:
Limited data from prospective cohort studies in high-income countries are available on the perinatal risk factors for common infections in children. Our hypothesis was that perinatal factors may be risk factors for infectious episodes during the first year of life.
Methods:
In this prospective Health and Early Life Microbiota birth cohort study of full-term infants (n = 1052) born in 2016–2018, the number and duration of infection episodes were collected online at weekly to monthly intervals. In a multivariate regression model, the main exposures were perinatal factors such as mode of delivery and intrapartum antibiotics. Environmental factors were additional exposures. The outcomes were the number and duration of infectious episodes in the first year of life.
Results:
The mean number of infection episodes was 4.2 (2.9 SD). The mean duration of infection symptoms was 44 days (40 SD). Upper respiratory infections accounted for 83% of the episodes (3674/4455). Perinatal factors were not associated with the number nor the duration of infection episodes, but cesarean section was associated with an increased occurrence of urinary tract infections in infancy [adjusted odds ratio (aOR): 3.6; 95% confidence interval (CI): 1.13–11.1]. Of the additional exposures male sex (aOR: 1.1; 95% CI: 1.0–1.2) and the presence of siblings (aOR: 1.3; 95% CI: 1.2–1.4) were associated with the number of infection episodes.
Conclusions:
This prospective cohort study showed that perinatal factors, mode of delivery and intrapartum antibiotics were not associated with the risk of common infections in infancy, but cesarean delivery was associated with a risk of urinary tract infections.
Objective:
Limited data from prospective cohort studies in high-income countries are available on the perinatal risk factors for common infections in children. Our hypothesis was that perinatal factors may be risk factors for infectious episodes during the first year of life.
Methods:
In this prospective Health and Early Life Microbiota birth cohort study of full-term infants (n = 1052) born in 2016–2018, the number and duration of infection episodes were collected online at weekly to monthly intervals. In a multivariate regression model, the main exposures were perinatal factors such as mode of delivery and intrapartum antibiotics. Environmental factors were additional exposures. The outcomes were the number and duration of infectious episodes in the first year of life.
Results:
The mean number of infection episodes was 4.2 (2.9 SD). The mean duration of infection symptoms was 44 days (40 SD). Upper respiratory infections accounted for 83% of the episodes (3674/4455). Perinatal factors were not associated with the number nor the duration of infection episodes, but cesarean section was associated with an increased occurrence of urinary tract infections in infancy [adjusted odds ratio (aOR): 3.6; 95% confidence interval (CI): 1.13–11.1]. Of the additional exposures male sex (aOR: 1.1; 95% CI: 1.0–1.2) and the presence of siblings (aOR: 1.3; 95% CI: 1.2–1.4) were associated with the number of infection episodes.
Conclusions:
This prospective cohort study showed that perinatal factors, mode of delivery and intrapartum antibiotics were not associated with the risk of common infections in infancy, but cesarean delivery was associated with a risk of urinary tract infections.
Kokoelmat
- Avoin saatavuus [34196]
Ellei muuten mainita, aineiston lisenssi on https://creativecommons.org/licenses/by/4.0/