Timing and frequency of oropharyngeal squamous cell carcinoma recurrences after treatment with curative intent
Autio, Timo J.; Atula, Timo; Jouhi, Lauri; Irjala, Heikki; Halme, Elina; Jouppila-Mättö, Anna; Mäkitie, Antti; Koivunen, Petri (2023-03-30)
Timo J. Autio, Timo Atula, Lauri Jouhi, Heikki Irjala, Elina Halme, Anna Jouppila-Mättö, Antti Mäkitie & Petri Koivunen (2023) Timing and frequency of oropharyngeal squamous cell carcinoma recurrences after treatment with curative intent, Acta Oto-Laryngologica, 143:4, 334-339, DOI: 10.1080/00016489.2023.2188892
This is an Accepted Manuscript version of the following article, accepted for publication in Acta Oto-Laryngologica. Timo J. Autio, Timo Atula, Lauri Jouhi, Heikki Irjala, Elina Halme, Anna Jouppila-Mättö, Antti Mäkitie & Petri Koivunen (2023) Timing and frequency of oropharyngeal squamous cell carcinoma recurrences after treatment with curative intent, Acta Oto-Laryngologica, 143:4, 334-339, DOI: 10.1080/00016489.2023.2188892. It is deposited under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
https://creativecommons.org/licenses/by-nc/4.0/
https://urn.fi/URN:NBN:fi-fe20231003138518
Tiivistelmä
Abstract
Background: The increasing number of patients under surveillance after treatment of human papillomavirus-related oropharyngeal squamous cell carcinoma (OPSCC) places a great burden on healthcare providers.
Aims/objectives: The aim of this study was to explore OPSCC recurrences in a long follow-up period: their site, frequency and timepoint after primary treatment, treatment and outcome. The secondary aim was to investigate if the recurrences are diagnosed on routine follow-up visits, and if the p16 status will have an effect on the pattern of recurrences.
Materials and methods: We analyzed recurrences within a 10-year follow-up period after completed curatively intended treatment among OPSCC patients in Finland treated between 2000 and 2009. Patient-, tumor-, treatment- and follow-up -related parameters were investigated.
Results: Out of 495 patients with no residual tumor during the first six months, 71 (14%) were diagnosed with a recurrence, of which 47 were locoregional and 28 were treated with curative intent. Of the recurrences, 86% were diagnosed during the first 36 months after primary treatment. Only ten recurrences appeared after 36 months. The median OS after recurrence was 10.9 months.
Conclusions: Routine follow-up longer than three years after treatment seems not to be effective in terms of detecting OPSCC recurrences.
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