Prognostic histological markers in oral tongue squamous cell carcinoma patients treated with (chemo)radiotherapy
Hyytiäinen, Aini; Mroueh, Rayan; Peltonen, Johanna; Wennerstrand, Pia; Mäkitie, Antti; Al-Samadi, Ahmed; Ventelä, Sami; Salo, Tuula (2023-03-10)
Hyytiäinen, A., Mroueh, R., Peltonen, J., Wennerstrand, P., Mäkitie, A., Al-Samadi, A., Ventelä, S. and Salo, T. (2023), Prognostic histological markers in oral tongue squamous cell carcinoma patients treated with (chemo)radiotherapy. APMIS, 131: 142-151. https://doi.org/10.1111/apm.13298
© 2023 Scandinavian Societies for Pathology, Medical Microbiology and Immunology. This is the peer reviewed version of the following article: Hyytiäinen, A., Mroueh, R., Peltonen, J., Wennerstrand, P., Mäkitie, A., Al-Samadi, A., Ventelä, S. and Salo, T. (2023), Prognostic histological markers in oral tongue squamous cell carcinoma patients treated with (chemo)radiotherapy. APMIS, 131: 142-151, which has been published in final form at https://doi.org/10.1111/apm.13298. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
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https://urn.fi/URN:NBN:fi-fe2023042739178
Tiivistelmä
Abstract
Treatment of oral tongue squamous cell carcinoma (OTSCC) frequently includes surgery with postoperative radiotherapy (RT) or chemoradiotherapy (CRT). Resistance to RT or CRT remains a major clinical challenge and highlights the need to identify predictive markers for it. We included 71 OTSCC patients treated with surgery combined with RT or CRT. We evaluated the association between tumor budding, tumor–stroma ratio (TSR), depth of invasion (DOI), tumor-infiltrating lymphocytes (TILs), hypoxia-inducible factor-1alpha (HIF-1alpha) expression, octamer-binding transcription factor 4 (OCT4) expression, high-endothelial venules (HEVs), and disease-free survival (DFS) using uni- and multivariate analyses. No significant association was observed between the different histological and molecular markers (TSR, DOI, TILs, HEV, HIF-1alph, OCT4) and DFS. However, an associative trend between DOI, budding, and DFS was noted. Further studies with larger cohorts are needed to explore the prognostic value of DOI and budding for OTSCC patients treated with postoperative RT or CRT.
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