Plasma protein changes reflect colorectal cancer development and associated inflammation
Urbiola-Salvador, Víctor; Jabłońska, Agnieszka; Miroszewska, Dominika; Huang, Qianru; Duzowska, Katarzyna; Drężek-Chyła, Kinga; Zdrenka, Marek; Śrutek, Ewa; Szylberg, Łukasz; Jankowski, Michał; Bała, Dariusz; Zegarski, Wojciech; Nowikiewicz, Tomasz; Makarewicz, Wojciech; Adamczyk, Agnieszka; Ambicka, Aleksandra; Przewoźnik, Marcin; Harazin-Lechowicz, Agnieszka; Ryś, Janusz; Filipowicz, Natalia; Piotrowski, Arkadiusz; Dumanski, Jan P.; Li, Bin; Chen, Zhi (2023-05-09)
Urbiola-Salvador V, Jabłońska A, Miroszewska D, Huang Q, Duzowska K, Drężek-Chyła K, Zdrenka M, Śrutek E, Szylberg Ł, Jankowski M, Bała D, Zegarski W, Nowikiewicz T, Makarewicz W, Adamczyk A, Ambicka A, Przewoźnik M, Harazin-Lechowicz A, Ryś J, Filipowicz N, Piotrowski A, Dumanski JP, Li B and Chen Z (2023) Plasma protein changes reflect colorectal cancer development and associated inflammation. Front. Oncol. 13:1158261. doi: 10.3389/fonc.2023.1158261
© 2023 Urbiola-Salvador, Jabłońska, Miroszewska, Huang, Duzowska, Drężek-Chyła, Zdrenka, Śrutek, Szylberg, Jankowski, Bała, Zegarski, Nowikiewicz, Makarewicz, Adamczyk, Ambicka, Przewoźnik, Harazin-Lechowicz, Ryś, Filipowicz, Piotrowski, Dumanski, Li and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
https://creativecommons.org/licenses/by/4.0/
https://urn.fi/URN:NBN:fi-fe20230906120190
Tiivistelmä
Abstract
Introduction: Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of death worldwide. Efficient non-invasive blood-based biomarkers for CRC early detection and prognosis are urgently needed.
Methods: To identify novel potential plasma biomarkers, we applied a proximity extension assay (PEA), an antibody-based proteomics strategy to quantify the abundance of plasma proteins in CRC development and cancer-associated inflammation from few μL of plasma sample.
Results: Among the 690 quantified proteins, levels of 202 plasma proteins were significantly changed in CRC patients compared to age-and-sex-matched healthy subjects. We identified novel protein changes involved in Th17 activity, oncogenic pathways, and cancer-related inflammation with potential implications in the CRC diagnosis. Moreover, the interferon γ (IFNG), interleukin (IL) 32, and IL17C were identified as associated with the early stages of CRC, whereas lysophosphatidic acid phosphatase type 6 (ACP6), Fms-related tyrosine kinase 4 (FLT4), and MANSC domain-containing protein 1 (MANSC1) were correlated with the late-stages of CRC.
Discussion: Further study to characterize the newly identified plasma protein changes from larger cohorts will facilitate the identification of potential novel diagnostic, prognostic biomarkers for CRC.
Kokoelmat
- Avoin saatavuus [34516]
