Prognostic markers for oral cancer : an overview of the current status and directions for future research
de Oliveira, Lilianny Querino Rocha; Almangush, Alhadi; Al-Samadi, Ahmed; Salo, Tuula; Coletta, Ricardo D. (2023-04-04)
de Oliveira, LQR, Almangush, A, Al-Samadi, A, Salo, T, Coletta, RD. Prognostic markers for oral cancer: An overview of the current status and directions for future research. J Oral Pathol Med. 2023; 52( 4): 288- 293. doi:10.1111/jop.13406
© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: de Oliveira, LQR, Almangush, A, Al-Samadi, A, Salo, T, Coletta, RD. Prognostic markers for oral cancer: An overview of the current status and directions for future research. J Oral Pathol Med. 2023; 52( 4): 288- 293, which has been published in final form at https://doi.org/10.1111/jop.13406. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
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https://urn.fi/URN:NBN:fi-fe2023053049522
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Abstract
In the last decades, the search for biomarkers for response to therapy and prognosis, with potential of providing information about the likely course and outcome of disease, has been intense in oral squamous cell carcinomas. Although several biomarkers, ranging from genetic and molecular alterations to clinical and histopathological features, have been described, only a few of them are used in routine practice. The aim of this review is to outline the recent advances in oral squamous cell carcinomas biomarkers, exploring those related to clinical and histopathological features, cancer cells and components of the tumor microenvironment. Future directions, highlighting the main issues that limit the clinical application of many of the potential biomarkers, are discussed.
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