Biogenesis of mesoporous silica nanoparticles enclosed in extracellular vesicles by mouse renal adenocarcinoma cells

Pratiwi, Feby Wijaya; Keerthanaa Balasubramanian Shanthi; Makieieva, Olha; Chen, Zih An; Zhyvolozhnyi, Artem; Miinalainen, Ilkka; Bart, Genevieve; Samoylenko, Anatoliy; Wu, Si-Han (2023-05-05)
 
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https://doi.org/10.1007/978-1-0716-3203-1_17

Pratiwi, Feby Wijaya
Keerthanaa Balasubramanian Shanthi
Makieieva, Olha
Chen, Zih An
Zhyvolozhnyi, Artem
Miinalainen, Ilkka
Bart, Genevieve
Samoylenko, Anatoliy
Wu, Si-Han
Humana Press
05.05.2023

Pratiwi, F.W. et al. (2023). Biogenesis of Mesoporous Silica Nanoparticles Enclosed in Extracellular Vesicles by Mouse Renal Adenocarcinoma Cells. In: Vainio, S. (eds) Cell-Secreted Vesicles. Methods in Molecular Biology, vol 2668. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3203-1_17

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© 2023 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
https://rightsstatements.org/vocab/InC/1.0/
doi:https://doi.org/https://doi.org/10.1007/978-1-0716-3203-1_17
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https://urn.fi/URN:NBN:fi-fe2023050942237
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Abstract

Integrating the versatility of synthetic nanoparticles to natural biomaterials, such as cells or cell membranes, has gained considerable attention as promising alternative cargo delivery platforms in recent years. Extracellular vesicles (EVs), natural nanomaterials composed of a protein-rich lipid bilayer secreted by cells, have also shown advantages and great potential as a nano delivery platform in combination with synthetic particles due to their specific natural properties in overcoming several biology hurdles possessed in the recipient cell. Therefore, the preservation of EV’s origin properties is critical for their application as nanocarriers. This chapter will describe the encapsulation procedure of MSN encapsulated in EV membrane derived from mouse renal adenocarcinoma (Renca) cells through biogenesis. The FMSN-enclosed EVs produced through this approach still contain preserved EV’s natural membrane properties.

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