Duration of clinical symptoms in children with acute respiratory infection
Paalanne, Niko; Honkila, Minna; Mattila, Suvi; Pokka, Tytti; Renko, Marjo; Tapiainen, Terhi (2023-03-10)
Paalanne, N, Honkila, M, Mattila, S, Pokka, T, Renko, M, Tapiainen, T. Duration of clinical symptoms in children with acute respiratory infection. Acta Paediatr. 2023; 112: 813– 819. https://doi.org/10.1111/apa.16607
© 2022 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Paalanne, N, Honkila, M, Mattila, S, Pokka, T, Renko, M, Tapiainen, T. Duration of clinical symptoms in children with acute respiratory infection. Acta Paediatr. 2023; 112: 813– 819, which has been published in final form at https://doi.org/10.1111/apa.16607. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
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https://urn.fi/URN:NBN:fi-fe2023042739102
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Abstract
Aim: To investigate duration of clinical symptoms associated with various respiratory viruses and with the co-detection of respiratory viral and bacterial pathogens.
Methods: This prospective cohort study included 737 acutely ill children treated in a paediatric emergency department prior to the COVID-19 pandemic. Nasal swab samples were analysed with multiplex PCR panels for 16 viral and 7 bacterial respiratory pathogens. Parents filled in a questionnaire about the symptoms at the time of the visit and 14 days afterwards.
Results: Persistent symptoms 2 weeks after the onset of acute illness were common: 32% of the patients with a coronavirus 229 E, NL63 or OC43 finding, 31% of those with human metapneumovirus and 25% of those with rhinovirus reported ongoing symptoms. At least one symptom lasting more than 4 weeks was observed in 3–4% of the children. Children with viral and bacterial co-detection had a longer duration of fever than those with only viral detection (3.3 days [SD 2.8] vs. 1.6 days [SD 2.4], p < 0.001).
Conclusion: Symptoms lasting for more than 2 to 4 weeks appear to be relatively frequent in all respiratory viral infections in children. Viral and bacterial co-detection may increase the duration of illness.
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