The number of the intraepithelial T cells correlate with the proliferation index in human bulbourethral gland epithelium
Boronikhina, Tatiana; Piavchenko, Gennadii; Venediktov, Artem; Kustavinova, Ekaterina; Mukhamedova, Svetlana; Kartashkina, Natalia; Kuznetsov, Sergey; Meglinski, Igor; Yatskovskiy, Alexander (2022-11-18)
Tatiana Boronikhina, Gennadii Piavchenko, Artem Venediktov, Ekaterina Kustavinova, Svetlana Mukhamedova, Natalia Kartashkina, Sergey Kuznetsov, Igor Meglinski, Alexander Yatskovskiy, The number of the intraepithelial T cells correlate with the proliferation index in human bulbourethral gland epithelium, Heliyon, Volume 8, Issue 11, 2022, e11658, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2022.e11658
© 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
https://creativecommons.org/licenses/by/4.0/
https://urn.fi/URN:NBN:fi-fe2023070790387
Tiivistelmä
Abstract
Background: Our study has immunohistochemically examined T cells localization and number as well as proliferative activity level for the bulbourethral gland epithelium in men of different ages, using monoclonal antibodies against CD45RO and proliferating cell nuclear antigen (PCNA).
Results: We have found that the T cells have been localized mainly in excretory ducts epithelium of the glands in any age group, meanwhile their relative number varies with age. The excretory ducts epithelium has shown a high proliferative activity when in acini the PCNA index has been low. Postnatal dynamics of the epithelium proliferative activity positively correlates with age-related density fluctuations in lymphocytic infiltration of the glands.
Conclusions: We consider that intraepithelial T cells may contribute to the regulation of epithelial cells proliferation in the bulbourethral glands.
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