Substance use confounds associations between peer victimization and aggression in adolescence with mental disorders in adulthood : a prospective birth cohort study
Sarala, Marian; Miettunen, Jouko; Alakokkare, Anni-Emilia; Mustonen, Antti; Scott, James G.; Thomas, Hannah J.; Hurtig, Tuula; Niemelä, Solja (2022-07-26)
Sarala, M., Miettunen, J., Alakokkare, A.-E., Mustonen, A., Scott, J. G., Thomas, H. J., Hurtig, T., & Niemelä, S. (2022). Substance use confounds associations between peer victimization and aggression in adolescence with mental disorders in adulthood: A prospective birth cohort study. Journal of Adolescence, 94, 996– 1007. https://doi.org/10.1002/jad.12080
© 2022 The Foundation for Professionals in Services for Adolescents. This is the peer reviewed version of the following article: Sarala, M., Miettunen, J., Alakokkare, A.-E., Mustonen, A., Scott, J. G., Thomas, H. J., Hurtig, T., & Niemelä, S. (2022). Substance use confounds associations between peer victimization and aggression in adolescence with mental disorders in adulthood: A prospective birth cohort study. Journal of Adolescence, 94, 996– 1007., which has been published in final form at https://doi.org/10.1002/jad.12080. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
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https://urn.fi/URN:NBN:fi-fe2023020325727
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Abstract
Introduction: Peer victimization and aggression in adolescence are associated with later mental health morbidity. However, studies examining this association have not controlled for adolescent substance use. We aimed to study the associations between peer victimization, peer aggression, and mental disorders in adulthood, adjusting for substance use in adolescence.
Methods: Participants were from the prospective Northern Finland Birth Cohort 1986. Data were available for 6682 individuals (70.8% of the original sample). Peer victimization and peer aggression were assessed with items from the Achenbach Youth Self Report at ages 15−16 years. Outcomes were nonorganic psychosis, anxiety disorder, mood disorder, substance use disorder, and any mental disorder (a none-vs-any indicator) at age 33 years collected from nationwide health care, insurance, and pension registers. Family structure, alcohol intoxication frequency, daily smoking, illicit drug use, and baseline psychopathology using Youth Self-Report total score, and parental mental disorders were considered as confounding factors.
Results: In multivariable analyses, the association between peer victimization and psychosis (Hazard ratio [HR]: 2.9, 95% confidence interval [CI]: 1.2−6.9, p = .020) and mood disorder (HR: 1.7, 95% CI: 1.2−2.4, p = .012) in females remained significant after adjusting for confounders. Other associations between female and male peer victimization or aggression and the studied outcomes attenuated after adjustments.
Conclusions: Some associations between peer victimization and aggression and later mental health morbidity are explained by adolescent substance use. For females, substance use does not account for the increased risk of psychosis and mood disorder in those who experience peer victimization.
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