Influence of farm environment on asthma during the life course : a population-based birth cohort study in Northern Finland
Kantomaa, Marko T.; Tolvanen, Mimmi; Halonen, Miia; Svanes, Cecilie; Järvelin, Marjo-Riitta; Sebert, Sylvain (2023-01-24)
Kantomaa MT, Tolvanen M, Halonen M, Svanes C, Järvelin M-R, Sebert S. Influence of Farm Environment on Asthma during the Life Course: A Population-Based Birth Cohort Study in Northern Finland. International Journal of Environmental Research and Public Health. 2023; 20(3):2128. https://doi.org/10.3390/ijerph20032128
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
https://creativecommons.org/licenses/by/4.0/
https://urn.fi/URN:NBN:fi-fe2023071290569
Tiivistelmä
Abstract
We investigated the influence of a farming environment on asthma at three time points from birth to 46 years using the Northern Finland Birth Cohort 1966 (n = 10,926). The prevalence of asthma was investigated by postal questionnaires at 14, 31 and 46 years of age. Exposure to a farming environment was assessed by a postal questionnaire at birth and at 31 and 46 years of age. Odds ratios (ORs) and their 95% confidence intervals (95% CIs) for the prevalence of asthma were obtained from multinomial logistic regression, stratified by sex. Being born in a farmer family was potentially causally associated with lower risk of asthma in males at 31 years of age (OR 0.56, 95% CI 0.37, 0.85) and in females at 46 years of age (OR 0.64, 95% CI 0.44, 0.95). Working as a farmer was not associated with asthma. Exposure to a farming environment in childhood may have a lifelong impact on developing asthma from birth through young adulthood and until middle age, indicating that ‘immune deviation’ may persist throughout life.
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