Macrodomain binding compound MRS 2578 inhibits alphavirus replication
Mattila, Sari; Merilahti, Pirjo; Wazir, Sarah; Quirin, Tania; Maksimainen, Mirko M.; Zhang, Yuezhou; Xhaard, Henri; Lehtiö, Lari; Ahola, Tero (2021-11-17)
Mattila, S., Merilahti, P., Wazir, S., Quirin, T., Maksimainen, M. M., Zhang, Y., Xhaard, H., Lehtiö, L., & Ahola, T. (2021). Macrodomain Binding Compound MRS 2578 Inhibits Alphavirus Replication. Antimicrobial Agents and Chemotherapy, 65(12), e01398-21, https://doi.org/10.1128/aac.01398-21
© American Society for Microbiology.
https://rightsstatements.org/vocab/InC/1.0/
https://urn.fi/URN:NBN:fi-fe2021122162296
Tiivistelmä
Abstract
Alphaviruses are positive-strand RNA viruses causing febrile disease. Macrodomain-containing proteins, involved in ADP-ribose-mediated signaling, are encoded by both host cells and several virus groups, including alphaviruses. In this study, compound MRS 2578 that targets the human ADP-ribose glycohydrolase MacroD1 inhibited Semliki Forest virus production as well as viral RNA replication and replicase protein expression. The inhibitor was similarly active in alphavirus trans-replication systems, indicating that it targets the viral RNA replication stage.
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