Women with polycystic ovary syndrome have poorer work ability and higher disability retirement rate at midlife : a Northern Finland Birth Cohort 1966 study
Kujanpää, Linda; Arffman, Riikka K; Vaaramo, Eeva; Rossi, Henna-Riikka; Laitinen, Jaana; Morin-Papunen, Laure; Tapanainen, Juha; Ala-Mursula, Leena; Piltonen, Terhi T (2022-08-04)
Kujanpää, L., Arffman, R. K., Vaaramo, E., Rossi, H.-R., Laitinen, J., Morin-Papunen, L., Tapanainen, J., Ala-Mursula, L., & Piltonen, T. T. (2022). Women with polycystic ovary syndrome have poorer work ability and higher disability retirement rate at midlife: A Northern Finland Birth Cohort 1966 study. European Journal of Endocrinology, 187(3), 479–488. https://doi.org/10.1530/EJE-22-0027
© 2022 The authors. Published by Bioscientifica Ltd. This work is licensed under a Creative Commons Attribution 4.0 International License.
https://creativecommons.org/licenses/by/4.0/
https://urn.fi/URN:NBN:fi-fe2022102763386
Tiivistelmä
Abstract
Objective: Polycystic ovary syndrome (PCOS) presents with multiple comorbidities potentially affecting function. This was the first general population-based study to evaluate work ability, participation in working life, and disability retirement in middle-aged women with and without PCOS.
Design: This is a cohort study.
Methods: Women with PCOS (n = 280) and women without PCOS symptoms or diagnosis (n = 1573) were identified in the Northern Finland Birth Cohort in 1966 and were evaluated for self-rated work ability and potential confounders at age 46. Next, incidence rate ratios (IRRs) for disability and unemployment days were extracted from national registers during a prospective 2-year follow-up. Lastly, we assessed hazard ratios (HRs) for disability retirement between 16 and 52 years of age from national registers.
Results: The women with PCOS reported poorer ability to work at age 46, especially due to poorer health. During the 2-year follow-up period, the affected women gained on average an additional month of disability and unemployment days, corresponding to an approximately 25% higher risk for both disability (IRR (95% CI): 1.25 (1.22–1.27)) and unemployment days (IRR (95% CI): 1.26 (1.23–1.28)) in models adjusted for health and socioeconomic factors. Lastly, we found a two-fold higher cumulative risk for disability retirement by age 52 compared to non-PCOS women (HR (95% CI): 1.98 (1.40–2.80)), which remained after adjusting for confounding factors (aHR (95% CI): 1.55 (1.01–2.38)).
Conclusions: PCOS is associated with lower participation in working life already in midlife. Acknowledging PCOS-related multimorbidity, concerted efforts are needed to support sustainable careers for women with PCOS.
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