Gut microbiome drives individual memory variation in bumblebees
Li, Li; Solvi, Cwyn; Zhang, Feng; Qi, Zhaoyang; Chittka, Lars; Zhao, Wei (2021-11-25)
Li, L., Solvi, C., Zhang, F. et al. Gut microbiome drives individual memory variation in bumblebees. Nat Commun 12, 6588 (2021). https://doi.org/10.1038/s41467-021-26833-4
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https://urn.fi/URN:NBN:fi-fe2022020817985
Tiivistelmä
Abstract
The potential of the gut microbiome as a driver of individual cognitive differences in natural populations of animals remains unexplored. Here, using metagenomic sequencing of individual bumblebee hindguts, we find a positive correlation between the abundance of Lactobacillus Firm-5 cluster and memory retention on a visual discrimination task. Supplementation with the Firm-5 species Lactobacillus apis, but not other non-Firm-5 bacterial species, enhances bees’ memory. Untargeted metabolomics after L. apis supplementation show increased LPA (14:0) glycerophospholipid in the haemolymph. Oral administration of the LPA increases long-term memory significantly. Based on our findings and metagenomic/metabolomic analyses, we propose a molecular pathway for this gut-brain interaction. Our results provide insights into proximate and ultimate causes of cognitive differences in natural bumblebee populations.
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