<em>methylclock</em> : a Bioconductor package to estimate DNA methylation age
Pelegí-Sisó, Dolors; de Prado, Paula; Ronkainen, Justiina; Bustamante, Mariona; González, Juan R. (2020-09-22)
Dolors Pelegí-Sisó, Paula de Prado, Justiina Ronkainen, Mariona Bustamante, Juan R González, methylclock: a Bioconductor package to estimate DNA methylation age, Bioinformatics, Volume 37, Issue 12, 15 June 2021, Pages 1759–1760, https://doi.org/10.1093/bioinformatics/btaa825
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https://urn.fi/URN:NBN:fi-fe2022013111515
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Abstract
Motivation: Ageing is a biological and psychosocial process related to diseases and mortality. It correlates with changes in DNA methylation (DNAm) in all human tissues. Therefore, epigenetic markers can be used to estimate biological age using DNAm profiling across tissues.
Results: We developed a Bioconductor package that allows computation of several existing DNAm adult/childhood and gestational age clocks. Functions to visualize the DNAm age prediction versus chronological age and the correlation between DNAm clocks are also available as well as other features, such as missing data imputation of cell types’ estimates, that are required for DNAm age clocks.
Availability and implementation: https://github.com/isglobal-brge/methylclock
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