Comprehensive meta-analysis of associations between temperament and character traits in Cloninger’s psychobiological theory and mental disorders

Komasi, Saeid; Rezaei, Farzin; Hemmati, Azad; Rahmani, Khaled; Amianto, Federico; Miettunen, Jouko (2022-01-07)
 
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URL:
https://doi.org/10.1177/03000605211070766

Komasi, Saeid
Rezaei, Farzin
Hemmati, Azad
Rahmani, Khaled
Amianto, Federico
Miettunen, Jouko
SAGE Publications
07.01.2022

Komasi, S., Rezaei, F., Hemmati, A., Rahmani, K., Amianto, F., & Miettunen, J. (2022). Comprehensive meta-analysis of associations between temperament and character traits in Cloninger’s psychobiological theory and mental disorders. Journal of International Medical Research. https://doi.org/10.1177/03000605211070766

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© The Author(s) 2022. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
https://creativecommons.org/licenses/by-nc/4.0/
doi:https://doi.org/10.1177/03000605211070766
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Abstract

Objectives: To explore the relationship between temperament and character traits in Cloninger’s psychobiological theory and mental disorders.

Methods: A systematic literature search was conducted of five international databases for all articles published in English between January 1990 and April 2019 (PROSPEROCRD42019133214). Owing to heterogeneity, pooled estimates of correlations for personality disorders and standardized mean differences for case-control studies related to other mental disorders were calculated using the random-effects method.

Results: The pooled effect sizes obtained from 149 studies showed that high harm avoidance (related to 22/24 diagnostic categories), low self-directedness (21/23), low cooperativeness (17/23), high self-transcendence (14/23), low reward dependence (11/24), high novelty-seeking (10/24), low novelty-seeking (7/24), high persistence (2/23), low persistence (2/23) and high reward dependence (2/24) were related to psychopathology.

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