Characteristics of preeclampsia in donor cell gestations
Ervaala, Attina; Laivuori, Hannele; Gissler, Mika; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Kajantie, Eero; Heinonen, Seppo; Wedenoja, Satu (2021-12-11)
Attina Ervaala, Hannele Laivuori, Mika Gissler, Juha Kere, Katja Kivinen, Anneli Pouta, Eero Kajantie, Seppo Heinonen, Satu Wedenoja, Characteristics of preeclampsia in donor cell gestations, Pregnancy Hypertension, Volume 27, 2022, Pages 59-61, ISSN 2210-7789, https://doi.org/10.1016/j.preghy.2021.12.005
© 2021 The Authors. Published by Elsevier B.V. on behalf of International Society for the Study of Hypertension in Pregnancy. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
https://creativecommons.org/licenses/by/4.0/
https://urn.fi/URN:NBN:fi-fe2022042530188
Tiivistelmä
Abstract
Pregnancies conceived through donor oocytes or sperm show increased risk for preeclampsia. We studied this issue in a preeclampsia case-control cohort (n = 2778), and found overrepresentation of donor cell gestations among women with preeclampsia (14/1627, 0.86%; OR 1.81; 95% CI: 1.07–3.08; P = 0.025) compared to the population data. Moreover, we observed excess of male births from donor cell pregnancies (male-to-female ratio 2.5 vs. 0.97; OR 2.57; 95% CI 1.02–6.36; P = 0.043). Maternal age (36.7 vs. 30.2; P < 0.0001) and preterm deliveries (64% vs. 38%; P = 0.046) distinguished donor cell gestations from other pregnancies with preeclampsia. These results support foreign fetal antigens as modulators of preeclampsia.
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