Perfluoroalkyl substances and abdominal aortic calcification
Koskela, Antti; Ducatman, Alan; Schousboe, John T.; Nahhas, Ramzi W.; Khalil, Naila (2022-04-01)
Koskela, Antti MD, PhD; Ducatman, Alan MD; Schousboe, John T. MD, PhD; Nahhas, Ramzi W. PhD; Khalil, Naila PhD. Perfluoroalkyl Substances and Abdominal Aortic Calcification. Journal of Occupational and Environmental Medicine: April 2022 - Volume 64 - Issue 4 - p 287-294 doi: 10.1097/JOM.0000000000002479
© 2022 American College of Occupational and Environmental Medicine. Unauthorized reproduction of this article is prohibited. The final authenticated version is available online at http://dx.doi.org/10.1097/jom.0000000000002479.
https://rightsstatements.org/vocab/InC/1.0/
https://urn.fi/URN:NBN:fi-fe2022092360008
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Abstract
Objectives: To evaluate if serum perfluoroalkylated substances (PFAS) were associated with abdominal aortic calcification (AAC).
Methods: We used weighted logistic regression to investigate the gender-specific association between PFAS serum levels and AAC more than or equal to 6 from dual-energy X-ray absorptiometry (DXA) scans of the thoraco-lumbar spine from National Health and Nutrition Examination Survey 2013–2014 survey participants aged more than or equal to 40 years.
Results: After adjusting for confounding, none of log-transformed perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonic acid (PFHxS), or perfluorononanoic acid (PFNA) were significantly associated with AAC for either men or women (adjusted odds ratios [ORs] ranged from 0.80 to 1.33, P> 0.05 each). For PFOA and PFOS, the association was positive only in women (although the difference was not statistically significant in either case).
Conclusions: These findings do not provide general support for a relationship of PFAS exposure to AAC, although the results show a need for gender-specific consideration in a larger dataset.
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