Effect of a multidomain lifestyle intervention on estimated dementia risk
Solomon, Alina; Handels, Ron; Wimo, Anders; Antikainen, Riitta; Laatikainen, Tiina; Levälahti, Esko; Peltonen, Markku; Soininen, Hilkka; Strandberg, Timo; Tuomilehto, Jaakko; Kivipelto, Miia; Ngandu, Tiia (2021-08-17)
Solomon, Alina et al. ‘Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk’. 1 Jan. 2021 : 1461–1466, https://doi.org/10.3233/JAD-210331
© 2021 – The authors. Published by IOS Press. This is an Open Access article distributed under the termsof the Creative Commons Attribution-NonCommercial License (CC BY-NC 4.0).
https://creativecommons.org/licenses/by-nc/4.0/
https://urn.fi/URN:NBN:fi-fe2021101451070
Tiivistelmä
Abstract
We investigated the effect of a multidomain lifestyle intervention on the risk of dementia estimated using the validated CAIDE risk score (post-hoc analysis). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year randomized controlled trial among 1,260 at-risk older adults (60–77 years). Difference in the estimated mean change in CAIDE score at 2 years in the intervention compared to the control group was –0.16 (95 %CI –0.31 to 0.00) (p = 0.013), corresponding to a relative dementia risk reduction between 6.04–6.50%. This could be interpreted as a reflection of the prevention potential of the intervention.
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