The influence of genetic syndromes on the algorithm of cleft lip and palate repair : a retrospective study
Sándor-Bajusz, Kinga Amália; Maros, Teodor Barna; Olasz, Lajos; Sándor, George Kálmán; Hadzsiev, Kinga; Vástyán, Attila Mihály (2021-11-29)
Sándor-Bajusz, K., Maros, T., Olasz, L., Sándor, G., Hadzsiev, K., & Vástyán, A. (2021). The influence of genetic syndromes on the algorithm of cleft lip and palate repair – A retrospective study. Annals of Maxillofacial Surgery, 11(2), 270. https://doi.org/10.4103/ams.ams_77_21
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https://urn.fi/URN:NBN:fi-fe2021120859585
Tiivistelmä
Abstract
Introduction: This study aimed to determine if the treatment algorithm used for nonsyndromic cleft patients required alteration to manage syndromic cleft lip and/or palate patients.
Methods: The records of patients managed by the Pécs Cleft Team between January 1999 and December 2015 were analyzed retrospectively. The sources of the data included clinical and genetic records.
Results: A total of 607 patients were managed by the cleft team during the study. Sixteen patients (2.6%) were noted to be afflicted with a particular identifiable syndrome. Seven different genetic syndromes and one sequence were present in the study. The Pierre Robin sequence occurred most often, comprising 50% of the cohort. The treatment algorithm used in managing nonsyndromic clefts required modification in 13 of the 16 syndromic patients.
Discussion: The presence of a genetic syndrome may notably affect the treatment algorithm in children born with cleft lip and/or palate. The surgical treatment of certain associated anomalies has by necessity, priority over the timing of the reconstruction of the cleft lip and/or cleft palate in syndromic patients.
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