Inverse correlation of fluctuations of cerebral blood and water concentrations in humans
Borchardt, Viola; Korhonen, Vesa; Helakari, Heta; Nedergaard, Maiken; Myllylä, Teemu; Kiviniemi, Vesa (2021-05-05)
Borchardt, V., Korhonen, V., Helakari, H. et al. Inverse correlation of fluctuations of cerebral blood and water concentrations in humans. Eur. Phys. J. Plus 136, 497 (2021). https://doi.org/10.1140/epjp/s13360-021-01480-2
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https://urn.fi/URN:NBN:fi-fe2021060936093
Tiivistelmä
Abstract
Near-infrared spectroscopy (fNIRS) measures concentrations of oxygenated (HbO) and deoxygenated (HbR) hemoglobin in the brain. Recently, we demonstrated its potential also for measuring concentrations of cerebral water (cH₂O). We performed fNIRS measurements during rest to study fluctuations in concentrations of cH₂O, HbO and HbR in 33 well-rested healthy control subjects (HC) and 18 acutely sleep-deprived HC. Resting-state fNIRS signal was filtered in full-band, cardiac, respiratory, low-, and very-low-frequency bands. The sum of HbO and HbR constitutes the regional cerebral blood volume (CBV). CBV and cH₂O concentrations were analyzed via temporal correlation and phase synchrony. Fluctuation in concentrations of cH₂O and CBV was strongly anti-correlated across all frequency bands in both frontal and parietal cortices. Fluctuation in concentrations of cH₂O and CBV showed neither a completely synchronous nor a random phase relationship in both frontal and parietal cortices. Acutely sleep-deprived subjects did not show significant differences in temporal correlation or phase synchrony between fluctuations in cH₂O and CBV concentrations compared with well-rested HC. The reciprocal interrelation between fluctuations in CBV and cH₂O concentrations is consistent with the Munro–Kellie doctrine of constant intracranial volume. This coupling may constitute a functional mechanism underlying glymphatic circulation, which persists despite acutely disturbed sleep patterns.
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