Central nervous system and ocular manifestations in puumala hantavirus infection

Hautala, Nina; Partanen, Terhi; Kubin, Anna-Maria; Kauma, Heikki; Hautala, Timo (2021-05-31)
 
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https://doi.org/10.3390/v13061040

Hautala, Nina
Partanen, Terhi
Kubin, Anna-Maria
Kauma, Heikki
Hautala, Timo
Multidisciplinary Digital Publishing Institute
31.05.2021

Hautala, N., Partanen, T., Kubin, A.-M., Kauma, H., & Hautala, T. (2021). Central Nervous System and Ocular Manifestations in Puumala Hantavirus Infection. Viruses, 13(6), 1040. doi:10.3390/v13061040

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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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doi:https://doi.org/10.3390/v13061040
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Abstract

Puumala hantavirus (PUUV), carried and spread by the bank vole (Myodes glareolus), causes a mild form of hemorrhagic fever with renal syndrome (HFRS) called nephropathia epidemica (NE). Acute high fever, acute kidney injury (AKI), thrombocytopenia, and hematuria are typical features of this syndrome. In addition, headache, blurred vision, insomnia, vertigo, and nausea are commonly associated with the disease. This review explores the mechanisms and presentations of ocular and central nervous system involvement in acute NE.

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