Allocation of rhodamine-loaded nanocapsules from blood circulatory system to adjacent tissues assessed in vivo by fluorescence spectroscopy
Tarakanchikova, Yana; Stelmashchuk, Olga; Seryogina, Evgeniya; Piavchenko, Gennadii; Zherebtsov, Evgeny; Dunaev, Andrey; Popov, Alexey; Meglinski, Igor (2018-08-21)
Tarakanchikova, Y., Stelmashchuk, O., Seryogina, E., Piavchenko, G., Zherebtsov, E., Dunaev, A., Popov, A., & Meglinski, I. (2018). Allocation of rhodamine-loaded nanocapsules from blood circulatory system to adjacent tissues assessedin vivoby fluorescence spectroscopy. In Laser Physics Letters (Vol. 15, Issue 10, p. 105601). IOP Publishing. https://doi.org/10.1088/1612-202x/aad857
© 2018 Astro Ltd. This is an author-created, un-copyedited version of an article published in Laser Physics Letters. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/1612-202x/aad857.
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https://urn.fi/URN:NBN:fi-fe2021110554138
Tiivistelmä
Abstract
Modern fluorescent modalities play an important role in the functional diagnostic of various physiological processes in living tissues. Utilizing the fluorescence spectroscopy approach we observe the circulation of fluorescent-labelled nanocapsules with rhodamine tetramethylrhodamine in a microcirculatory blood system. The measurements were conducted transcutaneously on the surface of healthy Wistar rat thighs in vivo. The administration of the preparation capsule suspension with a rhodamine concentration of 5 mg kg⁻¹ of the animal weight resulted in a two-fold increase of fluorescence intensity relative to the baseline level. The dissemination of nanocapsules in the adjacent tissues via the circulatory system was observed and assessed quantitatively. The approach can be used for the transdermal assessment of rhodamine-loaded capsules in vivo.
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