Prolyl and lysyl hydroxylases in collagen synthesis
Salo, Antti M.; Myllyharju, Johanna (2020-09-23)
Salo, AM, Myllyharju, J. Prolyl and lysyl hydroxylases in collagen synthesis. Exp Dermatol 2021; 30: 38– 49. https://doi.org/10.1111/exd.14197
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Salo, AM, Myllyharju, J. Prolyl and lysyl hydroxylases in collagen synthesis. Exp Dermatol 2021; 30: 38– 49, which has been published in final form at https://doi.org/10.1111/exd.14197. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
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https://urn.fi/URN:NBN:fi-fe202102023537
Tiivistelmä
Abstract
Collagens are the most abundant proteins in the extracellular matrix. They provide a framework to build organs and tissues and give structural support to make them resistant to mechanical load and forces. Several intra‐ and extracellular modifications are needed to make functional collagen molecules, intracellular post‐translational modifications of proline and lysine residues having key roles in this. In this article, we provide a review on the enzymes responsible for the proline and lysine modifications, that is collagen prolyl 4‐hydroxylases, 3‐hydroxylases and lysyl hydroxylases, and discuss their biological functions and involvement in diseases.
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